Last updated on October 2018

Pembrolizumab for HPV-associated Recurrent Respiratory Papilloma Patients With Laryngeal Tracheal and/or Pulmonary Involvement

Brief description of study

This research study is evaluating an immune modulatory agent as a possible treatment for patients with Recurrent Respiratory Papillomatosis (RRP) with significant disease involving the larynx, trachea, and/or lungs. The investigators will be using Pembrolizumab as the treating agent.

Detailed Study Description

This research study is a Phase II clinical trial. Phase II clinical trials test the safety and effectiveness of an investigational intervention to learn whether the intervention works in treating a specific disease. The FDA (the U.S. Food and Drug Administration) has not approved Pembrolizumab for your specific disease but it has been approved for other uses.

Pembrolizumab is a humanized monoclonal antibody. Pembrolizumab is being studied in several other clinical trials to see if it has an effect in helping the immune system to recognize and eliminate abnormal cells in the body. The antibody blocks a receptor expressed on immune cells, called T cells, and by blocking this receptor it has the potential to activate the T cells to kill abnormal cells, such as virally infected cells.

In this research study, the investigators are looking at whether Pembrolizumab can restore the natural ability of the immune system to recognize and eliminate Human papillomavirus (HPV)-infected cells from the body.

Clinical Study Identifier: NCT02632344

Contact Investigators or Research Sites near you

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Aaron Friedman, MD

NorthShore University HealthSystem
Evanston, IL United States
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Sara Pai, MD, PhD

Massachusetts General Hospital
Boston, MA United States
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Recruitment Status: Open

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