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Last updated on December 2019

A Study Evaluating Safety Pharmacokinetics and Therapeutic Activity of RO6874281 as a Single Agent (Part A) or in Combination With Trastuzumab or Cetuximab (Part B or C)

Brief description of study

This first-in-human, open-label, multicenter, Phase Ia/Ib, adaptive, multiple ascending-dose study will evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary anti-tumor activity of RO6874281 as a single agent (Part A) or in combination with trastuzumab or cetuximab (Part B or C).

Clinical Study Identifier: NCT02627274

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University of Arizona Cancer Center

Tucson, AZ United States
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UCSD - Moores Cancer Center

La Jolla, CA United States
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University of Colorado Hospital - Anschutz Cancer Pavilion

Aurora, CO United States
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Memorial Sloan Kettering

New York, NY United States
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Centre Georges Francois Leclerc

Dijon, France
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Centre Leon Berard

Lyon, France
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Institut Claudius Regaud; Departement Oncologie Medicale

Toulouse, France
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Antoni Van Leeuwenhoek Ziekenhuis; Gastro-Enterologie

Amsterdam, Netherlands
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Erasmus MC

Rotterdam, Netherlands
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Clinica Universitaria de Navarra

Pamplona, Spain
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Hospital del Mar; Servicio de Oncologia

Barcelona, Spain
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Hospital Univ Vall d'Hebron; Servicio de Oncologia

Barcelona, Spain
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Hospital Universitario 12 de Octubre; Servicio de Oncologia

Madrid, Spain
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Hospital Clinico Universitario de Valencia; Servicio de Onco-hematologia

Valencia, Spain
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Leicester Royal Infirmary

Leicester, United Kingdom
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Barts Health NHS Trust - St Bartholomew's Hospital

London, United Kingdom
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Christie Hospital

Manchester, United Kingdom
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Fondazione IRCCS Istituto Nazionale dei Tumori;S.S. Trattamento MedicoTumori dellaTesta e delCollo

Milano, Italy
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Istituto Europeo di Oncologia; Svil. Nuovi Farmaci per Terapie Innovative

Milano, Italy
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Azienda Socio Sanitaria Territoriale Niguarda (Ospedale Niguarda Ca' Granda); Oncologico -Onc.Falck

Milano, Italy
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UZ Antwerpen

Edegem, Belgium
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Institut Bergonie; Oncologie

Bordeaux, France
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Institut Gustave Roussy; Sitep

VILLEJUIF Cedex, France
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Ospedale Policlinico S. Matteo; Phase I Clinical Trial Unit and Experimental Therapy

Pavia, Italy
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Guys and St Thomas NHS Foundation Trust, Guys Hospital

London, United Kingdom
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Banner MD Anderson Cancer Center

Gilbert, AZ United States
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Washington University; Division of Oncology

Saint Louis, MO United States
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The Ohio State University

Columbus, OH United States
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Juravinski Cancer Clinic; Department of Oncology

Hamilton, ON Canada
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University Health Network; Princess Margaret Hospital; Medical Oncology Dept

Toronto, ON Canada
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Jewish General Hospital / McGill University

Montreal, QC Canada
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Rigshospitalet; Onkologisk Klinik

København Ø, Denmark
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