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Last updated on December 2018

A Study Evaluating Safety Pharmacokinetics and Therapeutic Activity of RO6874281 as a Single Agent (Part A) or in Combination With Trastuzumab or Cetuximab (Part B or C)

Brief description of study

This first-in-human, open-label, multicenter, Phase Ia/Ib, adaptive, multiple ascending-dose study will evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary anti-tumor activity of RO6874281 as a single agent (Part A) or in combination with trastuzumab or cetuximab (Part B or C).

Clinical Study Identifier: NCT02627274

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University of Arizona Cancer Center
Tucson, AZ United States
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UCSD - Moores Cancer Center
La Jolla, CA United States
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University of Colorado Hospital - Anschutz Cancer Pavilion
Aurora, CO United States
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Memorial Sloan Kettering
New York, NY United States
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Centre Georges Francois Leclerc
Dijon, France
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Centre Leon Berard
Lyon, France
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Institut Claudius Regaud; Departement Oncologie Medicale
Toulouse, France
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Antoni Van Leeuwenhoek Ziekenhuis; Gastro-Enterologie
Amsterdam, Netherlands
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Erasmus MC
Rotterdam, Netherlands
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Clinica Universitaria de Navarra
Pamplona, Spain
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Hospital del Mar; Servicio de Oncologia
Barcelona, Spain
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Hospital Univ Vall d'Hebron; Servicio de Oncologia
Barcelona, Spain
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Hospital Universitario 12 de Octubre; Servicio de Oncologia
Madrid, Spain
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Hospital Clinico Universitario de Valencia; Servicio de Onco-hematologia
Valencia, Spain
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Leicester Royal Infirmary
Leicester, United Kingdom
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Barts Health NHS Trust - St Bartholomew's Hospital
London, United Kingdom
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Christie Hospital
Manchester, United Kingdom
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Fondazione IRCCS Istituto Nazionale dei Tumori;S.S. Trattamento MedicoTumori dellaTesta e delCollo
Milano, Italy
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Istituto Europeo di Oncologia; Svil. Nuovi Farmaci per Terapie Innovative
Milano, Italy
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Azienda Socio Sanitaria Territoriale Niguarda (Ospedale Niguarda Ca' Granda); Oncologico -Onc.Falck
Milano, Italy
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UZ Antwerpen
Edegem, Belgium
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Reference Study ID Number: BP29842 ...

Rigshospitalet; Onkologisk Klinik
København Ø, Denmark
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Recruitment Status: Open

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