Last updated on August 2019

A Study Evaluating Safety Pharmacokinetics and Therapeutic Activity of RO6874281 as a Single Agent (Part A) or in Combination With Trastuzumab or Cetuximab (Part B or C)


Brief description of study

This first-in-human, open-label, multicenter, Phase Ia/Ib, adaptive, multiple ascending-dose study will evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary anti-tumor activity of RO6874281 as a single agent (Part A) or in combination with trastuzumab or cetuximab (Part B or C).

Clinical Study Identifier: NCT02627274

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UCSD - Moores Cancer Center

La Jolla, CA United States
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Memorial Sloan Kettering

New York, NY United States
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Erasmus MC

Rotterdam, Netherlands
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Leicester Royal Infirmary

Leicester, United Kingdom
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Christie Hospital

Manchester, United Kingdom
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UZ Antwerpen

Edegem, Belgium
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The Ohio State University

Columbus, OH United States
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