Last updated on July 2019

A Study of Obinutuzumab Rituximab Polatuzumab Vedotin and Venetoclax in Relapsed or Refractory Follicular Lymphoma (FL) or Diffuse Large B-Cell Lymphoma (DLBCL)


Brief description of study

This study will evaluate the safety, efficacy, and pharmacokinetics of induction treatment with obinutuzumab, polatuzumab vedotin, and venetoclax in participants with relapsed or refractory FL, and with rituximab, polatuzumab vedotin, and venetoclax in participants with DLBCL. Participants with FL who achieve complete response (CR), partial response (PR), or stable disease (SD) at the end of induction therapy will receive post-induction treatment with obinutuzumab and venetoclax, and participants with DLBCL who achieve CR or PR at the end of induction (EOI) will receive post-induction treatment with rituximab and venetoclax.

Clinical Study Identifier: NCT02611323

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Yale Cancer Center

New Haven, CT United States
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Memorial Healthcare System

Pembroke, FL United States
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University of Michigan

Ann Arbor, MI United States
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Roswell Park Cancer Inst.

Buffalo, NY United States
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Fox Chase Cancer Center

Philadelphia, PA United States
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Scott and White

Temple, TX United States
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Recruitment Status: Open


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