ABI-009, an mTOR Inhibitor, for Patients With Severe Pulmonary Arterial Hypertension

  • STATUS
    Not Recruiting
  • End date
    Dec 18, 2023
  • participants needed
    25
  • sponsor
    Aadi, LLC
Updated on 14 September 2022
pulmonary function test
primary pulmonary hypertension
congenital heart defects
pulmonary arterial hypertension
left ventricular end-diastolic pressure

Summary

mTOR activation has been shown to be relevant in the development and progression of pulmonary hypertension. Inhibition of mTOR has been shown to reverse or regress pulmonary hypertension in animal models. ABI-009 is an albumin-bound mTOR inhibitor with improved penetration in lung tissue.

Details
Condition Pulmonary Hypertension
Treatment ABI-009, nab-rapamycin, albumin-bound rapamycin
Clinical Study IdentifierNCT02587325
SponsorAadi, LLC
Last Modified on14 September 2022

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