Last updated on February 2018

Sustained Effect of Droxidopa in Symptomatic Neurogenic Orthostatic Hypotension


Brief description of study

To evaluate the time to treatment intervention in patients with Parkinson's Disease (PD), Multiple System Atrophy (MSA), Pure Autonomic Failure (PAF), Non-Diabetic Autonomic Neuropathy (NDAN) or Dopamine Beta Hydroxylase (DBH) Deficiency who have been previously stabilized with droxidopa therapy for symptoms of neurogenic orthostatic hypotension (NOH) (dizziness, light-headedness, or feelings that they are about to black out)

Detailed Study Description

This is a multi-site, placebo-controlled, double-blind, randomized withdrawal, time to intervention study with a duration of up to 36 weeks, consisting of 5 periods:

Screening Period: up to 4 weeks duration; Open-Label Titration Period (Titration Period): up to 4 weeks duration; Open-Label Treatment Period (Open-Label Period): 12 weeks duration; Double-Blind Treatment Period (Double-Blind Period): 12 weeks duration; Safety Follow-Up Period: 4 weeks duration

Clinical Study Identifier: NCT02586623

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21st Century Neurology
Phoenix, AZ United States
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Sherri Felton

Movement Disorders Center of Arizona
Scottsdale, AZ United States
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Kenneth Lee

Center For Neurosciences
Tucson, AZ United States
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Eddie Soto

University of Arizona Health Sciences Center, Department Of Neurology
Tucson, AZ United States
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Bobbi Phillips

Arkansas Cardiology Clinic
Little Rock, AR United States
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Alyssa Ferdinando

East Bay Physicians Medical Group
Berkeley, CA United States
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Rosie Magallon

The Parkinson's and Movement Disorder Institute
Fountain Valley, CA United States
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Inez Betancourt

Behavioral Research Specialists, LLC
Glendale, CA United States
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Julie Lacanlale

Loma Linda University Medical Center
Loma Linda, CA United States
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Daniel Freire

University Of Southern California
Los Angeles, CA United States
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Cassie Tran

Neurosearch, Inc. - Pasedena
Pasadena, CA United States
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Neurosearch, Inc. - Ventura
Pasadena, CA United States
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Johnny Tran

Neurosearch, Inc. - Reseda
Reseda, CA United States
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Tammy Donnel

Sutter Neuroscience
Sacramento, CA United States
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Janet Stolowitz

The Parkinson's Institute and Clinical Center
Sunnyvale, CA United States
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Ted Satyadi

Neurosearch Inc. - Torrance
Torrance, CA United States
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Jodi Ventimiglia

Colorado Springs Neurological Associates
Colorado Springs, CO United States
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B. Habibi

Associated Neurologists, P.C.
Danbury, CT United States
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Associated Neurologists of Southern Connecticut, P.C.
Fairfield, CT United States
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Sheila Thurlow

Eastern Connecticut Neurology Specialists, LLC
Manchester, CT United States
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Sean Montague

Georgetown University
Washington, D.C., United States
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Lauren Mullens

Parkinson's Disease And Movement Disorders Center of Boca Raton
Boca Raton, FL United States
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Julie Segura

UF Center for Movement Disorders and Neurorestoration
Gainesville, FL United States
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Donna Flowers

Neurology Associates
Maitland, FL United States
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New Life Medical Research Center
Miami Lakes, FL United States
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Sindia Cordero

Future Clinical Research
Miami, FL United States
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Monica Quesada

University Of Miami - Jackson Memorial Hospital, Dept. of Neurology
Miami, FL United States
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Julie Nelson

Neurostudies, Inc.
Port Charlotte, FL United States
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Judy Seymour

Parkinson's Disease Treatment Center of Southwest Florida
Port Charlotte, FL United States
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Cheryl Lesko

USF Parkinson's & Movement Disorders Center
Tampa, FL United States
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Vickie Bussey

Vero Neurology
Vero Beach, FL United States
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Mary L Weeks

Emory University
Atlanta, GA United States
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Paula Jackson

Georgia Regents University
Augusta, GA United States
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Paul Adapon

Hawaii Pacific Neuroscience
Honolulu, HI United States
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Anna Rutkowski

Northwestern Medical Group
Chicago, IL United States
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Kelli Jones

Rush University Medical Center - Department Of Cardiology
Chicago, IL United States
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Lucia Blasucci

Rush University Medical Center, Department of Neurology
Chicago, IL United States
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Komal Sharma

Central Dupage Hospital
Winfield, IL United States
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Brian Lynn

Maine Medical Partners Technology
Scarborough, ME United States
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Massachusetts General Hospital - Movement Disorders Clinic
Boston, MA United States
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Stacey Brown

Autonomic and Movement Disorders
Boston, MA United States
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Aubrey Alexander

Michigan State University, Department of Neurology
East Lansing, MI United States
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Linda Gojcevic

Detroit Clinical Research Center
Farmington Hills, MI United States
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Mercy Health - St. Mary's
Grand Rapids, MI United States
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Brenda Bygden

Northern Michigan Neurology
Traverse City, MI United States
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Patricia Kaminski

Henry Ford West Bloomfield Hospital
West Bloomfield Township, MI United States
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Adrienne Carney

Platte Valley Medical Group
Kearney, NE United States
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Dru McMarten

Methodist Physicians Clinic - Heart Consultants
Omaha, NE United States
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Jonathan Beck

The Nebraska Medical Center
Omaha, NE United States
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Charlotte Jeffreys

Dartmouth-Hitchcock Medical Center
Lebanon, NH United States
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Brianna DeCarvalho

JFK Neuroscience Institution
Edison, NJ United States
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Sofya Glazman

SUNY Downstate Medical Center
Brooklyn, NY United States
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Nancy Gardella

David L. Kreitzman MD, PC
Commack, NY United States
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Meaghan Caruso

Neurology Associates of West Chester
Hawthorne, NY United States
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Parker Jewish Institute for Health Care & Rehabilitation
New Hyde Park, NY United States
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Joan Bratton

The Bendheim Parkinson and Movement Disorders Center
New York, NY United States
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Tiffany Harding

Island Neurological Associates
Plainview, NY United States
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Muhammad Sami

Alpha Neurology
Staten Island, NY United States
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Helen Hayes Hospital
West Haverstraw, NY United States
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Janice Rucker

Neurosciences Institute
Charlotte, NC United States
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Jordan Norman

Insight Neuroscience, LLC
Bellevue, OH United States
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Wendy Thacker

Dayton Center for Neurological Disorders
Centerville, OH United States
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Luba Osadchy

Riverhills Healthcare, Inc.
Cincinnati, OH United States
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Cleveland Clinic - Taussig Cancer Institute
Cleveland, OH United States
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Katy Groezinger

Ohio Health Research Institute
Columbus, OH United States
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Ohio State University, Department of Neurology
Columbus, OH United States
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Julia Spears

Medical College of Ohio, Department of Neurology
Toledo, OH United States
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COR Clinical Research, LLC
Oklahoma City, OK United States
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St. Luke's Neurology Associates
Bethlehem, PA United States
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A. Morris

Penn State Milton S. Hershey Medical Center
Hershey, PA United States
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Christina Maxwell

Drexel Neurosciences Institute
Philadelphia, PA United States
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Suzanne Reichwein

University of Pennsylvania, Parkinson's Disease & Movement Disorders Center
Philadelphia, PA United States
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Sherri Mosovsky

University of Pittsburgh, Department of Neurology
Pittsburgh, PA United States
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Jing Belfiglio

Vanderbilt University Autonomic Dysfunction Center - Clinical Trials Center
Nashville, TN United States
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Steve Hopkins

UT Southwestern Medical Center
Dallas, TX United States
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Beth Latham

University of Texas Health Science Center at Houston
Houston, TX United States
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Koni Lopez

Central Texas Neurology Consultants
Round Rock, TX United States
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Jennifer Bland

Bateman Home Center
Salt Lake City, UT United States
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Tricia Brannon

Inova Health Systems
Alexandria, VA United States
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Lindsay Wegner

Integrated Neurology Services, PLLC
Falls Church, VA United States
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Grace Jordan

Sentara Neurology Specialists
Norfolk, VA United States
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Gwendolyn Darby

Henrico Doctors Neurology Associates, LLC
Richmond, VA United States
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Anhaita Jamula

Booth Gardner Parkinson's Care Center
Kirkland, WA United States
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Laurie Peterson

Premeir Clinical Research
Spokane, WA United States
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Diane Richardson

Grafton Medical Office
Grafton, WI United States
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