Last updated on May 2019

Sustained Effect of Droxidopa in Symptomatic Neurogenic Orthostatic Hypotension


Brief description of study

To evaluate the time to treatment intervention in patients with Parkinson's Disease (PD), Multiple System Atrophy (MSA), Pure Autonomic Failure (PAF), Non-Diabetic Autonomic Neuropathy (NDAN) or Dopamine Beta Hydroxylase (DBH) Deficiency who have been previously stabilized with droxidopa therapy for symptoms of neurogenic orthostatic hypotension (NOH) (dizziness, light-headedness, or feelings that they are about to black out)

Detailed Study Description

This is a multi-site, placebo-controlled, double-blind, randomized withdrawal, time to intervention study with a duration of up to 36 weeks, consisting of 5 periods:

Screening Period: up to 4 weeks duration; Open-Label Titration Period (Titration Period): up to 4 weeks duration; Open-Label Treatment Period (Open-Label Period): 12 weeks duration; Double-Blind Treatment Period (Double-Blind Period): 12 weeks duration; Safety Follow-Up Period: 4 weeks duration

Clinical Study Identifier: NCT02586623

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Georgia Regents University

Augusta, GA United States
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Insight Neuroscience, LLC

Bellevue, OH United States
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Alpha Neurology

Staten Island, NY United States
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Bateman Home Center

Salt Lake City, UT United States
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Inova Health Systems

Alexandria, VA United States
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Neurology Associates

Maitland, FL United States
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Sutter Neuroscience

Sacramento, CA United States
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David L. Kreitzman MD, PC

Commack, NY United States
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Future Clinical Research

Miami, FL United States
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Center For Neurosciences

Tucson, AZ United States
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Premeir Clinical Research

Spokane, WA United States
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Colorado Springs Neurological Associates

Colorado Springs, CO United States
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University Of Southern California

Los Angeles, CA United States
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Vero Neurology

Vero Beach, FL United States
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Neurostudies, Inc.

Port Charlotte, FL United States
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Neurosearch, Inc. - Pasedena

Pasadena, CA United States
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Neurosciences Institute

Charlotte, NC United States
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Northern Michigan Neurology

Traverse City, MI United States
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Georgetown University

Washington, D.C., United States
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Northwestern Medical Group

Chicago, IL United States
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Island Neurological Associates

Plainview, NY United States
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Henry Ford West Bloomfield Hospital

West Bloomfield Township, MI United States
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Grafton Medical Office

Grafton, WI United States
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Hawaii Pacific Neuroscience

Honolulu, HI United States
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Maine Medical Partners Technology

Scarborough, ME United States
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21st Century Neurology

Phoenix, AZ United States
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Arkansas Cardiology Clinic

Little Rock, AR United States
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Central Dupage Hospital

Winfield, IL United States
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Platte Valley Medical Group

Kearney, NE United States
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Neurosearch Inc. - Torrance

Torrance, CA United States
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Riverhills Healthcare, Inc.

Cincinnati, OH United States
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Drexel Neurosciences Institute

Philadelphia, PA United States
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Detroit Clinical Research Center

Farmington Hills, MI United States
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Emory University

Atlanta, GA United States
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MDFirst Research - Chandler

Chandler, AZ United States
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Focilmed

Oxnard, CA United States
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Neurosearch - Pasadena

Pasadena, CA United States
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Neurosearch, Inc. - Ventura

Pasadena, CA United States
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Georgetown University

Washington, WA United States
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New Life Medical Research Center

Miami Lakes, FL United States
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Mercy Health - St. Mary's

Grand Rapids, MI United States
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Henry Ford West Bloomfield Hospital

West Bloomfield, MI United States
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Helen Hayes Hospital

West Haverstraw, NY United States
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COR Clinical Research, LLC

Oklahoma City, OK United States
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Recruitment Status: Open


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