Last updated on June 2019

A Study to Test the Effect of the Drug Larotrectinib in Adults and Children With NTRK-fusion Positive Solid Tumors

Brief description of study

This research study is done to test how well different types of cancer respond to the drug called larotrectinib. The cancer must have a change in a particular gene (NTRK1, NTRK2 or NTRK3). Larotrectinib is an experimental drug that blocks the actions of these NTRK genes in cancer cells and can therefore be used to treat cancer.

Detailed Study Description

The primary objective of this study is to investigate the efficacy of larotrectinib for the treatment of advanced solid tumors harboring a fusion of neurotrophic tyrosine receptor kinase (NTRK) of types 1-3 in children and adults.

Secondary objectives comprise the efficacy and safety of larotrectinib in different NTRK-tumor types.

Clinical Study Identifier: NCT02576431

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Stanford Cancer Center

Palo Alto, CA United States
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UCLA-Santa Monica Medical Center

Santa Monica, CA United States
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Memorial Hospital West

Pembroke, FL United States
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University of Chicago

Chicago, IL United States
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Wake Forest Baptist Health

Winston-Salem, NC United States
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Cleveland Clinic

Cleveland, OH United States
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Thomas Jefferson University

Philadelphia, PA United States
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Fox Chase Cancer Center

Philadelphia, PA United States
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Avera Cancer Institute

Sioux Falls, SD United States
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Inova Health Care Services

Falls Church, VA United States
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University of Washington

Seattle, WA United States
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West Virginia University

Morgantown, WV United States
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Finsen Centre

Copenhagen, Denmark
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Samsung Medical Center

Seoul, Korea, Republic of
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Southampton General Hospital

Southampton, United Kingdom
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Recruitment Status: Open

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