Last updated on November 2019

Standard vs. Accelerated Initiation of RRT in Acute Kidney Injury (STARRT-AKI: Principal Trial)

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Acute renal failure
  • Age: Between 18 - 100 Years
  • Gender: Male or Female

Inclusion Criteria:

  1. Age 18 years
  2. Admission to an intensive care unit (ICU)
  3. Evidence of kidney dysfunction [serum creatinine 100 mol/L (women) and 130 mol/L (men)]
  4. Evidence of severe AKI defined by at least 1 of the following 3 criteria:
  5. 2-fold increase in serum creatinine from a known pre-morbid baseline or during the current hospitalization; OR ii) Achievement of a serum creatinine 354 mol/L with evidence of a minimum increase of 27 mol/L from pre-morbid baseline or during the current hospitalization; OR iii) Urine output < 6.0 mL/kg over the preceding 12 hours

Exclusion Criteria:

  1. Serum potassium > 5.5 mmol/L
  2. Serum bicarbonate < 15 mmol/L
  3. Presence of a drug overdose that necessitates initiation of RRT
  4. Lack of commitment to ongoing life support (including RRT)
  5. Any RRT within the previous 2 months (either acute or chronic RRT)
  6. Kidney transplant within the past 365 days
  7. Known pre-hospitalization advanced chronic kidney disease, defined by an estimated glomerular filtration rate < 20 mL/min/1.73 m2
  8. Presence or clinical suspicion of renal obstruction, rapidly progressive glomerulonephritis, vasculitis, thrombotic microangiopathy or acute interstitial nephritis
  9. Clinician(s) caring for patient believe(s) that immediate RRT is mandated
  10. Clinician(s) caring for patient believe(s) that deferral of RRT initiation is mandated
    • at their discretion, clinicians may administer a bolus of intravenous furosemide (ie, "furosemide stress test") and evaluate the subsequent urine output to help guide decision making regarding the likelihood of AKI progression

Recruitment Status: Closed

Brief Description Eligibility Contact Research Team

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