Last updated on December 2018

The Efficacy and Safety of Initial Triple Versus Initial Dual Oral Combination Therapy in Patients With Newly Diagnosed Pulmonary Arterial Hypertension

Brief description of study

The objective of this clinical trial is to compare the efficacy and safety of an initial triple oral treatment regimen (macitentan, tadalafil, selexipag) versus an initial dual oral treatment regimen (macitentan, tadalafil, placebo) in newly diagnosed, treatment-nave patients with pulmonary arterial hypertension.

Clinical Study Identifier: NCT02558231

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Jeremy Feldman

Arizona Pulmonary Specialists, LTD
Phoenix, AZ United States
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David Poch

UCSD Health Sciences
La Jolla, CA United States
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Rajan Saggar

UCLA Medical Center
Los Angeles, CA United States
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Franck Rahaghi

Cleveland Clinic Florida
Weston, FL United States
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Piedmont Pulmonary and Critical Care Research
Atlanta, GA United States
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Linda Cadaret

University of Iowa Hospitals & Clinics
Iowa City, IA United States
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John McConnell

Kentuckiana Pulmonary Associates
Louisville, KY United States
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Ioana Preston

Tufts Medical Center
Boston, MA United States
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Elisabeth Klings

Boston University Medical Center
Boston, MA United States
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Vallerie McLaughlin

The Regents of the University of Michigan
Ann Arbor, MI United States
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Murali Chakinala

Washington University School of Medicine
Saint Louis, MI United States
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Peter Engel

The Christ Hospital
Cincinnati, OH United States
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Raymond Benza

Allegheny General Hospital of Research
Pittsburgh, PA United States
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Michael Mathier

UPMC Presbyterian
Pittsburgh, PA United States
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Kelly Chin

University of Texas Southwestern Medical Center
Dallas, TX United States
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Adaani Frost

Houston Methodist Hospital
Houston, TX United States
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Anne Keogh

St. Vincents Hospital Sydney
Darlinghurst, Australia
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Horst Olschewski

LKH -Universit t Klinkum Graz
Graz, Austria
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Regina Steringer-Maschenbauer

Krankenhaus der Elisabethinen Linz
Linz, Austria
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Jean-Luc Vachiéry

H pital Erasme
Brussels, Belgium
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Catharina Belge

UZ Leuven - Campus Gasthuisberg
Leuven, Belgium
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John Swiston

Vancouver General Hospital
Vancouver, BC Canada
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Sanjay Mehta

London Health Sciences Centre - Victoria Hospital
London, ON Canada
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John Granton

University of Toronto
Toronto, ON Canada
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David Langleben

Jewish General Hospital
Montreal, QC Canada
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Steve Provencher

Institut Universitaire de Cardiologie et de Pneumologie de Qu bec
Quebec City, QC Canada
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Michael Halank

Unversit tsklinikum Carl Gustav Carus
Dresden, Germany
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Ardeschir Ghofrani

Universit tsklinikum Giessen
Giessen, Germany
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Hans Klose

Universit tsklinikum Hamburg-Eppendorf
Hamburg, Germany
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Marius Hoepter

Medizinische Hochschule Hannover
Hannover, Germany
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Ekkehard Grünig

Universit tsklinikum Heidelberg
Heidelberg, Germany
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Nazzareno Galiè

Ospedale Sant'Orsola
Bologna, Italy
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Charles Burger

Mayo Clinic Jacksonville
Jacksonville, FL United States
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Hector Cajigas

Northwestern University
Chicago, IL United States
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Lana Melendres-Groves

University of New Mexico Hospital
New Orleans, LA United States
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Paul Hassoun

Johns Hopkins School of Medicine
Baltimore, MD United States
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David Celermajer

Royal Prince Albert Hospital
Camperdown, Australia
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Trevor Williams

The Alfred Hospital
Melbourne, Australia
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Irene Lange

AKH Wien
Wien, Austria
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Loic Perchenet

University of Calgary
Calgary, Canada
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Lisa Marie Mielniczuk

University of Ottawa Heart Institute
Ottawa, Canada
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Jens Nielsen-Kudsk

Aarhus University Hospital Skejby
Aarhus, Denmark
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Jorn Carlsen

Rigshospitalet Copenhagen
Copenhagen, Denmark
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Xavier Jaïs

CHU de Bic tre
Le Kremlin-Bicêtre, France
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Stephan Rosenkranz

Universit tsklinikum K ln
Köln, Germany
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Tobias Lange

Universit tsklinikum Regensburg
Regensburg, Germany
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Matthias Held

Klinikum W rzburg Mitte gGmbH
Würzburg, Germany
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Matthias Held

Missions rztliche Klinik W rzburg
Würzburg, Germany
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Laura Scelsi

Ambulatorio Scompenso Cardiaco e Trapianti
Pavia, Italy
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Bogaard Jan

VUmc Amsterdam
Amsterdam, Netherlands
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Pieter van Paassen

Maastricht University Medical Center
Maastricht, Netherlands
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Karin Boomars

Erasmus Medical Center Rotterdam
Rotterdam, Netherlands
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Nicolai Johannessen

Haukeland University hospital Bergen
Bergen, Norway
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Göran Radegran

Sk nes universitetssjukhus Lund
Lund, Sweden
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Stefan Söderberg

Norrlands universitetssjukhus
Umeå, Sweden
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Gerhard Wikström

Uppsala, Sweden
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Silvia Ulrich

Universi tsspital Z rich
Zürich, Switzerland
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Recruitment Status: Open

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