Last updated on February 2018

Efficacy of Suvorexant to Treat Insomnia Related to Bipolar Disorder

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Bipolar Disorder | Insomnia
  • Age: Between 18 - 100 Years
  • Gender: Male or Female

Inclusion Criteria:

  1. Adult outpatients meeting Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) criteria for bipolar I disorder (296.70), bipolar II disorder (296.89), or bipolar disorder not otherwise specified (296.80), with concurrent insomnia related to bipolar disorder (307.42).
  2. Currently taking 1 prescription psychotropic medication (hypnotic agents, anxiolytics, atypical antipsychotics, mood stabilizers, and/or antidepressants) for management of bipolar disorder.
  3. Subjective total sleep time (sTST) < 6 hours on 1 night during the prior week.

Exclusion Criteria:

  1. Current hypo/manic symptoms, as evidenced by YMRS total score 12.
  2. Current (past 6 months) alcohol or substance use disorder.
  3. Current psychosis.
  4. Patients who are actively suicidal or evaluated as being a high suicide risk.
  5. Women who are currently pregnant or breastfeeding.
  6. Clinically significant abnormalities on baseline laboratory tests (comprehensive metabolic panel, fasting lipid panel, CBC with differential, thyroid stimulating hormone).
  7. Presence of any unstable and/or potentially confounding neurological and/or medical disorder.

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

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