Last updated on September 2018

Metronomic Chemotherapy in Patients With Advanced Solid Tumor With Bone Metastasis and Advanced Pretreated Osteosarcoma


Brief description of study

This is a prospective open-labeled phase I trial based on a dose escalating study design assessing two dose levels of sirolimus when prescribed in combination with metronomic cyclophosphamide (CP), methotrexate (MT) and zoledronic acid (ZA) followed by an expansion cohort once the Maximum Tolerated Dose (MTD) is established.

Detailed Study Description

The dose escalation part of the trial will be concerned on adults with advanced solid tumor with bone metastasis and young and adult patients with unresectable locally advanced or metastatic osteosarcoma.

The Expansion cohort will be conducted on young and adult patients with unresectable locally advanced or metastatic osteosarcoma.

Clinical Study Identifier: NCT02517918

Contact Investigators or Research Sites near you

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Julien DOMONT, Doctor

Institut Gustave Roussy
Villejuif Cedex, France
7.18miles
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Recruitment Status: Open


Brief Description Eligibility Contact Research Team


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