Last updated on July 2015

Endostar Treatment of Advanced Non-small Cell Lung Cancer Multi-center Clinical Research

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Non-small Cell Lung Cancer
  • Age: Between 18 - 75 Years
  • Gender: Male or Female
  • Other:
    Histologic confirmation cytology or not in patients undergoing single sputum cytology
    in the diagnosis of patients with non-small cell lung cancer;
    according to a new IASLC2009 lung cancer TNM stages judged the preious untreated
    tage IIIB or IV non-small cell lung cancer (with the exception of EGFR/ALK mutations
    must have at least one according to the RRECIST version 1.1 standard judgment to
    evaluate lesions (at least 10 mm, maximum diameter on spiral CT plain CT longest
    diameter at least 20 mm);
    male or female, age 18 and 75 years old or less or more;
    ECOG PS 0 ~ 1 minute;
    is expected to survive period for 3 months or more,
    enough blood function: absolute neutrophil count (ANC) or 2 x 109 / L and the
    platelet count 100 x 109 / L or higher acuity 9 g/dL and hemoglobin;
    Liver function enough: upper limit of total bilirubin acuities were normal (ULN); AST
    and ALT acuities were 2.5 times the upper limit of normal (ULN); Alkaline phosphatase
    5 times the upper limit of normal or less (ULN);
    enough renal function, serum creatinine or less normal limit (ULN) or calculated
    creatinine clearance or 60 mL/min.
    basic normal ecg, had on the body to heal wounds;
    always not received anti-tumor drug therapy, or always only for non metastatic tumor
    of adjuvant or neoadjuvant chemotherapy, but to study treatment has ended more than
    ix months at the beginning;
    ever had had surgery patients, request to study treatment began to have more than 4
    weeks, and the patient has recovered;
    a complete uterus of female in the group within 28 days before the study must have a
    negative pregnancy test results (except amenorrhea has 24 months). If the pregnancy
    test from the first time for more than 7 days, is the need for urine pregnancy test
    validation (within 7 days before the first delivery).
    prior to biological agents, especially e. coli genetically engineered products
    without severe allergic reactions;
    signed informed consent.

You may not be eligible for this study if the following are true:

  • pregnancy, nursing mothers, or fertility but not women using contraception;
    the existing serious acute infection, and not be controlled; Or fester sex and
    chronic infection, wound in delay no more;
    the original serious heart disease, including: higher risk of congestive heart
    failure, unable to control arrhythmia, unstable angina, myocardial infarction, severe
    valvular heart disease, and resistant hypertension;
    is not easy to control nerve, mental illness or mental disorders, compliance is poor,
    can't cooperate with accounts and response to treatment; Primary brain tumors or CNS
    metastases illness did not get a control, has obvious symptoms in cranial
    hypertension or nerve spirit;
    with bleeding tendency;
    other researchers believe that patients should not participate in this test.

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

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