Last updated on December 2018

AZD9291 Versus Placebo in Patients With Stage IB-IIIA Non-small Cell Lung Carcinoma Following Complete Tumour Resection With or Without Adjuvant Chemotherapy.


Brief description of study

To assess the efficacy and safety of AZD9291 versus Placebo, in patients with Epidermal Growth Factor Receptor Mutation Positive stage IB-IIIA non-small cell lung carcinoma, following complete tumour resection with or without adjuvant chemotherapy

Detailed Study Description

This is a phase 3 double-blind, randomized, placebo-controlled, study to assess the efficacy and safety of AZD9291 versus placebo in patients with stage IB-IIIA non-small cell lung cancer (NSCLC) with centrally confirmed, most common sensitising EGFR mutations (Ex19Del and L858R) either alone or in combination with other EGFR mutations as confirmed by a central test, who have had complete tumour resection, with or without postoperative adjuvant chemotherapy. Adjuvant chemotherapy should have consisted of a platinum based doublet given for a maximum of 4 cycles.

Clinical Study Identifier: NCT02511106

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Santa Monica, CA United States
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Norwalk, CT United States
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Fort Myers, FL United States
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Saint Petersburg, FL United States
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West Palm Beach, FL United States
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Athens, GA United States
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Chicago, IL United States
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Elk Grove Village, IL United States
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Marrero, LA United States
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Bethesda, MD United States
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Canton, OH United States
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Cincinnati, OH United States
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Cleveland, OH United States
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Chattanooga, TN United States
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Woolloongabba, Australia
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Brussels (Anderlecht), Belgium
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Cachoeira De Itapemirim, Brazil
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Rio Grande do Sul, Brazil
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São José do Rio Preto, Brazil
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