Last updated on December 2018

Corticosteroids + Bevacizumab vs. Corticosteroids + Placebo (BEST) for Radionecrosis After Radiosurgery for Brain Metastases


Brief description of study

This randomized phase II study aims to investigate whether the addition of bevacizumab to standard corticosteroid therapy results in greater improvement in symptoms and less treatment-induced symptoms compared with standard corticosteroid therapy for patients with symptomatic brain radionecrosis following radiosurgery. It is hypothesized that the addition of bevacizumab to standard care corticosteroids will reduce treatment-induced toxicities and improve neurologic impairments in patients with brain radionecrosis following radiosurgery for brain metastases.

Detailed Study Description

This is a randomized double-blinded phase II study of corticosteroids with bevacizumab vs. corticosteroids with placebo for brain radionecrosis following radiosurgery for brain metastases. This is a two-arm clinical trial with parallel group design for longitudinal quality of life endpoint. Patients will be stratified according to age ( 65 years vs. > 65 years), pathological confirmation of necrosis (yes vs. no), MDASI-BT mean global score (symptom + interference scores) ( < 4.0 vs. > 4.0) and prior whole brain radiotherapy (yes vs. no). The primary and secondary objectives are detailed below.

Primary Objective:

To investigate whether the addition of bevacizumab to standard corticosteroid therapy results in greater improvement in symptoms (clinical and patient-reported symptom improvement associated with radionecrosis and less radionecrosis treatment-induced symptoms) compared with standard corticosteroid therapy.

Secondary Objectives:

  1. To evaluate the toxicity profile associated with bevacizumab and corticosteroid therapy.
  2. To compare self-reported health related quality of life (HRQOL) using LASA, Dexamethasone Symptoms Questionnaire-Chronic (DSQ-C), and MDASI-BT symptom and interference score between treatment arms.
  3. To compare intracranial progression-free survival and time to maximum radiographic response between treatment arms.
  4. To compare the dose and duration of corticosteroids required between treatment arms and correlate steroid requirement with DSQ-C and MDASI-BT scores.

Patient event monitoring will occur every 2 months after treatment up to 6 months. Then event monitoring will occur up to one year.

Clinical Study Identifier: NCT02490878

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Caroline Chung, MD

Anchorage Associates in Radiation Medicine
Anchorage, AK United States

Caroline Chung, MD

Anchorage Radiation Therapy Center
Anchorage, AK United States

Caroline Chung, MD

Alaska Breast Care and Surgery LLC
Anchorage, AK United States

Caroline Chung, MD

Alaska Oncology and Hematology LLC
Anchorage, AK United States

Caroline Chung, MD

Alaska Women's Cancer Care
Anchorage, AK United States

Caroline Chung, MD

Anchorage Oncology Centre
Anchorage, AK United States

Caroline Chung, MD

Katmai Oncology Group
Anchorage, AK United States

Caroline Chung, MD

Providence Alaska Medical Center
Anchorage, AK United States

Caroline Chung, MD

Providence Saint Joseph Medical Center/Disney Family Cancer Center
Burbank, CA United States

Gregory A. Masters

Beebe Medical Center
Lewes, DE United States

Gregory A. Masters

Delaware Clinical and Laboratory Physicians PA
Newark, DE United States

Gregory A. Masters

Helen F Graham Cancer Center
Newark, DE United States

Gregory A. Masters

Medical Oncology Hematology Consultants PA
Newark, DE United States

Gregory A. Masters

Regional Hematology and Oncology PA
Newark, DE United States

Gregory A. Masters

Christiana Care Health System-Christiana Hospital
Newark, DE United States

Gregory A. Masters

Beebe Health Campus
Rehoboth Beach, DE United States

Gregory A. Masters

Nanticoke Memorial Hospital
Seaford, DE United States

Gregory A. Masters

Christiana Care Health System-Wilmington Hospital
Wilmington, DE United States

Sajeel A. Chowdhary

Boca Raton Regional Hospital
Boca Raton, FL United States

Ruby Anne E. Deveras

Halifax Health Medical Center-Centers for Oncology
Daytona Beach, FL United States

Christopher E. Haberman

Summit Cancer Care-Memorial
Savannah, GA United States

Caroline Chung, MD

Low Country Cancer Care Associates PC
Savannah, GA United States

Christopher M. Reynolds

Saint Alphonsus Cancer Care Center-Boise
Boise, ID United States

Caroline Chung, MD

Saint Luke's Mountain States Tumor Institute
Boise, ID United States

Christopher M. Reynolds

Saint Alphonsus Cancer Care Center-Caldwell
Caldwell, ID United States

Benjamin T. Marchello

Kootenai Medical Center
Coeur d'Alene, ID United States

Christopher M. Reynolds

Walter Knox Memorial Hospital
Emmett, ID United States

Caroline Chung, MD

Saint Luke's Mountain States Tumor Institute - Fruitland
Fruitland, ID United States

Christopher M. Reynolds

Idaho Urologic Institute-Meridian
Meridian, ID United States

Caroline Chung, MD

Saint Luke's Mountain States Tumor Institute - Meridian
Meridian, ID United States

Christopher M. Reynolds

Saint Alphonsus Medical Center-Nampa
Nampa, ID United States

Caroline Chung, MD

Saint Luke's Mountain States Tumor Institute - Nampa
Nampa, ID United States

Benjamin T. Marchello

Kootenai Cancer Center
Post Falls, ID United States

Benjamin T. Marchello

Kootenai Cancer Clinic
Sandpoint, ID United States

Caroline Chung, MD

Saint Luke's Mountain States Tumor Institute-Twin Falls
Twin Falls, ID United States

Kendrith M. Rowland

Rush - Copley Medical Center
Aurora, IL United States

Aidnag Z. Diaz

Rush University Medical Center
Chicago, IL United States

Kendrith M. Rowland

Carle on Vermilion
Danville, IL United States

Kendrith M. Rowland

Carle Physician Group-Effingham
Effingham, IL United States

Kendrith M. Rowland

Carle Physician Group-Mattoon/Charleston
Mattoon, IL United States

Kendrith M. Rowland

Carle Cancer Center
Urbana, IL United States

Kendrith M. Rowland

The Carle Foundation Hospital
Urbana, IL United States

Kendrith M. Rowland

Rush-Copley Healthcare Center
Yorkville, IL United States

Kendrith M. Rowland

Deaconess Clinic Downtown
Evansville, IN United States

Thomas J. Reid

Memorial Regional Cancer Center Day Road
Mishawaka, IN United States

Kendrith M. Rowland

Chancellor Center for Oncology
Newburgh, IN United States

Caroline Chung, MD

Reid Health
Richmond, IN United States

Thomas J. Reid

Memorial Hospital of South Bend
South Bend, IN United States

Robert J. Behrens

Iowa Methodist Medical Center
Des Moines, IA United States

Robert J. Behrens

Medical Oncology and Hematology Associates-Des Moines
Des Moines, IA United States

Robert J. Behrens

Broadlawns Medical Center
Des Moines, IA United States

Robert J. Behrens

Iowa Lutheran Hospital
Des Moines, IA United States

Robert J. Behrens

Methodist West Hospital
West Des Moines, IA United States

Caroline Chung

Alliance for Clinical Trials in Oncology
Boston, MA United States

Christopher M. Reynolds

Saint Joseph Mercy Hospital
Ann Arbor, MI United States

Christopher M. Reynolds

IHA Hematology Oncology Consultants-Brighton
Brighton, MI United States

Christopher M. Reynolds

Saint Joseph Mercy Brighton
Brighton, MI United States

Christopher M. Reynolds

IHA Hematology Oncology Consultants-Canton
Canton, MI United States

Christopher M. Reynolds

Caro Cancer Center
Caro, MI United States

Christopher M. Reynolds

IHA Hematology Oncology Consultants-Chelsea
Chelsea, MI United States

Christopher M. Reynolds

Saint Joseph Mercy Chelsea
Chelsea, MI United States

Christopher M. Reynolds

Hematology Oncology Consultants-Clarkston
Clarkston, MI United States

Christopher M. Reynolds

Newland Medical Associates-Clarkston
Clarkston, MI United States

Caroline Chung, MD

Beaumont Hospital-Dearborn
Dearborn, MI United States

Christopher M. Reynolds

Saint John Hospital and Medical Center
Detroit, MI United States

Christopher M. Reynolds

Great Lakes Cancer Management Specialists-Doctors Park
East China Township, MI United States

Christopher M. Reynolds

Hurley Medical Center
Flint, MI United States

Christopher M. Reynolds

Genesee Cancer and Blood Disease Treatment Center
Flint, MI United States

Christopher M. Reynolds

Genesee Hematology Oncology PC
Flint, MI United States

Christopher M. Reynolds

Genesys Hurley Cancer Institute
Flint, MI United States

Christopher M. Reynolds

Great Lakes Cancer Management Specialists-Van Elslander Cancer Center
Grosse Pointe Woods, MI United States

Christopher M. Reynolds

Lymphoma Clinic of Michigan
Grosse Pointe Woods, MI United States

Christopher M. Reynolds

Michigan Breast Specialists-Grosse Pointe Woods
Grosse Pointe Woods, MI United States

Caroline Chung, MD

William Beaumont Hospital-Grosse Point
Grosse Pointe, MI United States

Caroline Chung, MD

Allegiance Health
Jackson, MI United States

Christopher M. Reynolds

Sparrow Hospital
Lansing, MI United States

Christopher M. Reynolds

Hope Cancer Clinic
Livonia, MI United States

Christopher M. Reynolds

Saint Mary Mercy Hospital
Livonia, MI United States

Christopher M. Reynolds

Michigan Breast Specialists-Macomb Township
Macomb, MI United States

Caroline Chung, MD

Assarian Cancer Center
Novi, MI United States

Christopher M. Reynolds

21st Century Oncology-Pontiac
Pontiac, MI United States

Christopher M. Reynolds

Hope Cancer Center
Pontiac, MI United States

Christopher M. Reynolds

Newland Medical Associates-Pontiac
Pontiac, MI United States

Christopher M. Reynolds

Saint Joseph Mercy Oakland
Pontiac, MI United States

John A. Ellerton

Lake Huron Medical Center
Port Huron, MI United States

Christopher M. Reynolds

Great Lakes Cancer Management Specialists-Rochester Hills
Rochester Hills, MI United States

Caroline Chung, MD

Michigan Cancer Specialists
Roseville, MI United States

Caroline Chung, MD

Oakland Colon and Rectal Association
Royal Oak, MI United States

Caroline Chung, MD

Cancer Care Associates PC
Royal Oak, MI United States

Caroline Chung, MD

Comprehensive Medical Center PLLC
Royal Oak, MI United States

Caroline Chung, MD

Hematology Oncology Consultants PC
Royal Oak, MI United States

Caroline Chung, MD

Oakland Medical Group
Royal Oak, MI United States

Caroline Chung, MD

William Beaumont Hospital-Royal Oak
Royal Oak, MI United States

Christopher M. Reynolds

Saint Mary's of Michigan
Saginaw, MI United States

Christopher M. Reynolds

Oncology Hematology Associates of Saginaw Valley PC
Saginaw, MI United States

Caroline Chung, MD

Providence Hospital-Southfield Cancer Center
Southfield, MI United States

Christopher M. Reynolds

Bhadresh Nayak MD PC-Sterling Heights
Sterling Heights, MI United States

Caroline Chung, MD

Premier Hematology Oncology Care
Sterling Heights, MI United States

Caroline Chung, MD

Mitchell Folbe MD PC
Sterling Heights, MI United States

Caroline Chung, MD

Michigan Institute of Urology-Town Center
Troy, MI United States

Caroline Chung, MD

Claudia BR Herke MD PC
Troy, MI United States

Caroline Chung, MD

Hematology Oncology Consultants PC-Troy
Troy, MI United States

Caroline Chung, MD

William Beaumont Hospital - Troy
Troy, MI United States

Christopher M. Reynolds

Great Lakes Cancer Management Specialists-Macomb Professional Building
Warren, MI United States

Christopher M. Reynolds

Macomb Hematology Oncology PC
Warren, MI United States

Christopher M. Reynolds

Michigan Breast Specialists-Warren
Warren, MI United States

Christopher M. Reynolds

Saint John Macomb-Oakland Hospital
Warren, MI United States

Christopher M. Reynolds

Saint Mary's Oncology/Hematology Associates of West Branch
West Branch, MI United States

Christopher M. Reynolds

Huron Gastroenterology PC
Ypsilanti, MI United States

Christopher M. Reynolds

IHA Hematology Oncology Consultants-Ann Arbor
Ypsilanti, MI United States

Bret E. Friday

Essentia Health Saint Joseph's Medical Center
Brainerd, MN United States

Bret E. Friday

Essentia Health Cancer Center
Duluth, MN United States

Bret E. Friday

Essentia Health Saint Mary's Medical Center
Duluth, MN United States

Bret E. Friday

Miller-Dwan Hospital
Duluth, MN United States

Bret E. Friday

Lake Region Healthcare Corporation-Cancer Care
Fergus Falls, MN United States

Elizabeth Yan

Mayo Clinic
Rochester, MN United States

Jian L. Campian

Siteman Cancer Center at West County Hospital
Creve Coeur, MO United States

Jian L. Campian

Washington University School of Medicine
Saint Louis, MO United States

Jian L. Campian

Siteman Cancer Center at Saint Peters Hospital
Saint Peters, MO United States

Benjamin T. Marchello

Community Hospital of Anaconda
Anaconda, MT United States

Benjamin T. Marchello

Billings Clinic Cancer Center
Billings, MT United States

Benjamin T. Marchello

Bozeman Deaconess Hospital
Bozeman, MT United States

Benjamin T. Marchello

Benefis Healthcare- Sletten Cancer Institute
Great Falls, MT United States

Benjamin T. Marchello

Great Falls Clinic
Great Falls, MT United States

Benjamin T. Marchello

Saint Peter's Community Hospital
Helena, MT United States

Benjamin T. Marchello

Kalispell Regional Medical Center
Kalispell, MT United States

Benjamin T. Marchello

Community Medical Hospital
Missoula, MT United States

John A. Ellerton

Carson Tahoe Regional Medical Center
Carson City, NV United States

John A. Ellerton

Cancer and Blood Specialists-Henderson
Henderson, NV United States

John A. Ellerton

Comprehensive Cancer Centers of Nevada - Henderson
Henderson, NV United States

John A. Ellerton

Las Vegas Cancer Center-Henderson
Henderson, NV United States

John A. Ellerton

Comprehensive Cancer Centers of Nevada-Southeast Henderson
Henderson, NV United States

John A. Ellerton

University Medical Center of Southern Nevada
Las Vegas, NV United States

John A. Ellerton

Cancer and Blood Specialists-Shadow
Las Vegas, NV United States

John A. Ellerton

Radiation Oncology Centers of Nevada Central
Las Vegas, NV United States

John A. Ellerton

21st Century Oncology
Las Vegas, NV United States

John A. Ellerton

HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
Las Vegas, NV United States

John A. Ellerton

HealthCare Partners Medical Group Oncology/Hematology-San Martin
Las Vegas, NV United States

John A. Ellerton

Radiation Oncology Centers of Nevada Southeast
Las Vegas, NV United States

John A. Ellerton

Cancer Therapy and Integrative Medicine
Las Vegas, NV United States

John A. Ellerton

Ann M Wierman MD LTD
Las Vegas, NV United States

John A. Ellerton

Cancer and Blood Specialists-Tenaya
Las Vegas, NV United States

John A. Ellerton

Comprehensive Cancer Centers of Nevada - Northwest
Las Vegas, NV United States

John A. Ellerton

HealthCare Partners Medical Group Oncology/Hematology-Tenaya
Las Vegas, NV United States

John A. Ellerton

Comprehensive Cancer Centers of Nevada-Summerlin
Las Vegas, NV United States

John A. Ellerton

Summerlin Hospital Medical Center
Las Vegas, NV United States

John A. Ellerton

Las Vegas Cancer Center-Medical Center
Las Vegas, NV United States

John A. Ellerton

Comprehensive Cancer Centers of Nevada
Las Vegas, NV United States

John A. Ellerton

Nevada Cancer Specialists-Fort Apache
Las Vegas, NV United States

John A. Ellerton

HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
Las Vegas, NV United States

John A. Ellerton

Comprehensive Cancer Centers of Nevada - Central Valley
Las Vegas, NV United States

John A. Ellerton

University Cancer Center
Las Vegas, NV United States

John A. Ellerton

Renown Regional Medical Center
Reno, NV United States

John A. Ellerton

Saint Mary's Regional Medical Center
Reno, NV United States

Douglas J. Weckstein

New Hampshire Oncology Hematology PA-Concord
Concord, NH United States

Douglas J. Weckstein

New Hampshire Oncology Hematology PA-Hooksett
Hooksett, NH United States

Caroline Chung, MD

Overlook Hospital
Summit, NJ United States

Dheerendra Prasad

Roswell Park Cancer Institute
Buffalo, NY United States

Andrew S. Chi

Laura and Isaac Perlmutter Cancer Center at NYU Langone
New York, NY United States

James N. Atkins

Southeastern Medical Oncology Center-Clinton
Clinton, NC United States

James N. Atkins

Southeastern Medical Oncology Center-Goldsboro
Goldsboro, NC United States

James N. Atkins

Wayne Memorial Hospital
Goldsboro, NC United States

James N. Atkins

Onslow Memorial Hospital
Jacksonville, NC United States

James N. Atkins

Southeastern Medical Oncology Center-Jacksonville
Jacksonville, NC United States

Caroline Chung, MD

Southeastern Medical Oncology Center-Wilson
Wilson, NC United States

Michael D. Chan

Wake Forest University Health Sciences
Winston-Salem, NC United States

Bret E. Friday

Essentia Health Cancer Center-South University Clinic
Fargo, ND United States

Caroline Chung, MD

Dayton Physicians LLC-Miami Valley South
Centerville, OH United States

Caroline Chung, MD

Miami Valley Hospital South
Centerville, OH United States

Caroline Chung, MD

Oncology Hematology Care Inc-Kenwood
Cincinnati, OH United States

Caroline Chung, MD

Good Samaritan Hospital - Dayton
Dayton, OH United States

Caroline Chung, MD

Miami Valley Hospital
Dayton, OH United States

Caroline Chung, MD

Dayton Physicians LLC-Samaritan North
Dayton, OH United States

Caroline Chung, MD

Samaritan North Health Center
Dayton, OH United States

Caroline Chung, MD

Armes Family Cancer Center
Findlay, OH United States

Caroline Chung, MD

Blanchard Valley Hospital
Findlay, OH United States

Caroline Chung, MD

Orion Cancer Care
Findlay, OH United States

Caroline Chung, MD

Atrium Medical Center-Middletown Regional Hospital
Franklin, OH United States

Caroline Chung, MD

Dayton Physicians LLC-Atrium
Franklin, OH United States

Caroline Chung, MD

Dayton Physicians LLC-Wayne
Greenville, OH United States

Caroline Chung, MD

Wayne Hospital
Greenville, OH United States

Caroline Chung, MD

Greater Dayton Cancer Center
Kettering, OH United States

Caroline Chung, MD

First Dayton Cancer Care
Kettering, OH United States

Caroline Chung, MD

Kettering Medical Center
Kettering, OH United States

Caroline Chung, MD

Dayton Physicians LLC-Signal Point
Middletown, OH United States

Caroline Chung, MD

Dayton Physicians LLC-Wilson
Sidney, OH United States

Caroline Chung, MD

Springfield Regional Cancer Center
Springfield, OH United States

Caroline Chung, MD

Springfield Regional Medical Center
Springfield, OH United States

Caroline Chung, MD

Dayton Physicians LLC-Upper Valley
Troy, OH United States

Caroline Chung, MD

Upper Valley Medical Center
Troy, OH United States

Christopher M. Reynolds

Saint Alphonsus Medical Center-Baker City
Baker City, OR United States

Caroline Chung, MD

Saint Charles Health System
Bend, OR United States

Caroline Chung, MD

Clackamas Radiation Oncology Center
Clackamas, OR United States

Caroline Chung, MD

Providence Oncology and Hematology Care Southeast
Clackamas, OR United States

Caroline Chung, MD

Bay Area Hospital
Coos Bay, OR United States

Caroline Chung, MD

Providence Newberg Medical Center
Newberg, OR United States

Christopher M. Reynolds

Saint Alphonsus Medical Center-Ontario
Ontario, OR United States

Caroline Chung, MD

Providence Willamette Falls Medical Center
Oregon City, OR United States

Caroline Chung, MD

Providence Portland Medical Center
Portland, OR United States

Caroline Chung, MD

Providence Saint Vincent Medical Center
Portland, OR United States

Christopher M. Reynolds

Lehigh Valley Hospital-Cedar Crest
Allentown, PA United States

Christopher M. Reynolds

Lehigh Valley Hospital - Muhlenberg
Bethlehem, PA United States

Gregory A. Masters

Christiana Care Health System-Concord Health Center
Chadds Ford, PA United States

Caroline Chung, MD

Roper Hospital
Charleston, SC United States

Caroline Chung, MD

Charleston Hematology Oncology Associates-Roper
Charleston, SC United States

Caroline Chung, MD

Lowcountry Hematology Oncology PA-North Charleston
Charleston, SC United States

Caroline Chung, MD

Bon Secours Saint Francis Hospital
Charleston, SC United States

Caroline Chung, MD

Lowcountry Hematology Oncology PA-West Ashley
Charleston, SC United States

Michael D. Zurenko

Greenville Health System Cancer Institute-Laurens
Clinton, SC United States

Michael D. Zurenko

Greenville Health System Cancer Institute-Easley
Easley, SC United States

Michael D. Zurenko

Greenville Health System Cancer Institute-Butternut
Greenville, SC United States

Michael D. Zurenko

Greenville Health System Cancer Institute-Faris
Greenville, SC United States

Michael D. Zurenko

Greenville Memorial Hospital
Greenville, SC United States

Michael D. Zurenko

Greenville Health System Cancer Institute-Eastside
Greenville, SC United States

Michael D. Zurenko

Greenville Health System Cancer Institute-Greer
Greer, SC United States

Caroline Chung, MD

Lowcountry Hematology Oncology PA-Mount Pleasant
Mount Pleasant, SC United States

Michael D. Zurenko

Greenville Health System Cancer Institute-Seneca
Seneca, SC United States

Michael D. Zurenko

Greenville Health System Cancer Institute-Spartanburg
Spartanburg, SC United States

Albert Attia

Vanderbilt-Ingram Cancer Center Cool Springs
Franklin, TN United States

Albert Attia

Vanderbilt Breast Center at One Hundred Oaks
Nashville, TN United States

Albert Attia

Vanderbilt University/Ingram Cancer Center
Nashville, TN United States

Barbara J. O'Brien

M D Anderson Cancer Center
Houston, TX United States

Caroline Chung, MD

Providence Regional Cancer System-Aberdeen
Aberdeen, WA United States

Caroline Chung, MD

Cancer Care Center at Island Hospital
Anacortes, WA United States

Caroline Chung, MD

PeaceHealth Saint Joseph Medical Center
Bellingham, WA United States

Caroline Chung, MD

Providence Regional Cancer System-Centralia
Centralia, WA United States

Caroline Chung, MD

Swedish Medical Center-Edmonds
Edmonds, WA United States

Caroline Chung, MD

Providence Regional Cancer Partnership
Everett, WA United States

Caroline Chung, MD

Swedish Cancer Institute-Issaquah
Issaquah, WA United States

Caroline Chung, MD

Kadlec Clinic Hematology and Oncology
Kennewick, WA United States

Caroline Chung, MD

Providence Regional Cancer System-Lacey
Lacey, WA United States

Caroline Chung, MD

PeaceHealth Saint John Medical Center
Longview, WA United States

Caroline Chung, MD

Pacific Gynecology Specialists
Seattle, WA United States

Caroline Chung, MD

Swedish Medical Center-Ballard Campus
Seattle, WA United States

Caroline Chung, MD

Kaiser Permanente Washington
Seattle, WA United States

Caroline Chung, MD

Swedish Medical Center-First Hill
Seattle, WA United States

Caroline Chung, MD

Swedish Medical Center-Cherry Hill
Seattle, WA United States

Caroline Chung, MD

Providence Regional Cancer System-Shelton
Shelton, WA United States

Caroline Chung, MD

Rockwood Clinic Cancer Treatment Center-Valley
Spokane Valley, WA United States

Caroline Chung, MD

Rockwood Cancer Treatment Center-DHEC-Downtown
Spokane, WA United States

Caroline Chung, MD

Rockwood North Cancer Treatment Center
Spokane, WA United States

Caroline Chung, MD

PeaceHealth Southwest Medical Center
Vancouver, WA United States

Caroline Chung, MD

Providence Saint Mary Regional Cancer Center
Walla Walla, WA United States

Caroline Chung, MD

Providence Regional Cancer System-Yelm
Yelm, WA United States

Aaron P. Provenzano

United Hospital Center
Bridgeport, WV United States

Aaron P. Provenzano

West Virginia University Healthcare
Morgantown, WV United States

Benjamin T. Marchello

Billings Clinic-Cody
Cody, WY United States

Benjamin T. Marchello

Welch Cancer Center
Sheridan, WY United States

Jeffrey N. Greenspoon

Juravinski Cancer Centre at Hamilton Health Sciences
Hamilton, ON Canada

David B. Shultz

University Health Network-Princess Margaret Hospital
Toronto, ON Canada

David Roberge

CHUM - Hopital Notre-Dame
Montreal, QC Canada

Caroline Chung, MD

Jewish General Hospital
Montreal, QC Canada

John A. Ellerton

PCR Oncology
Arroyo Grande, CA United States

David E. Piccioni

UC San Diego Moores Cancer Center
La Jolla, CA United States

Robert Cavaliere

Baptist MD Anderson Cancer Center
Jacksonville, FL United States

Caroline Chung, MD

Mayo Clinic in Florida
Jacksonville, FL United States

Sepideh Mokhtari

Moffitt Cancer Center
Tampa, FL United States

Caroline Chung, MD

Summit Cancer Care-Candler
Savannah, GA United States

Michelle M. Kim

University of Michigan Comprehensive Cancer Center
Ann Arbor, MI United States

Christopher M. Reynolds

Saint Joseph Mercy Canton
Canton, MI United States

Christopher M. Reynolds

Great Lakes Cancer Management Specialists-Macomb Medical Campus
Macomb, MI United States

Christopher M. Reynolds

Saint Mary's Oncology/Hematology Associates of Marlette
Marlette, MI United States

Christopher M. Reynolds

Advanced Breast Care Center PLLC
Warren, MI United States

Christopher M. Reynolds

Bhadresh Nayak MD PC-Warren
Warren, MI United States

Bret E. Friday

Essentia Health Virginia Clinic
Virginia, MN United States

John A. Ellerton

Comprehensive Cancer Centers of Nevada-Horizon Ridge
Henderson, NV United States

John A. Ellerton

Nevada Cancer Specialists-Saint Rose
Henderson, NV United States

John A. Ellerton

21st Century Oncology-Henderson
Henderson, NV United States

John A. Ellerton

Desert West Surgery
Las Vegas, NV United States

John A. Ellerton

Nevada Cancer Specialists?Oakey
Las Vegas, NV United States

John A. Ellerton

21st Century Oncology-Vegas Tenaya
Las Vegas, NV United States

John A. Ellerton

Nevada Cancer Specialists-Tenaya
Las Vegas, NV United States

John A. Ellerton

21st Century Oncology-Fort Apache
Las Vegas, NV United States

John A. Ellerton

Hope Cancer Care of Nevada-Pahrump
Pahrump, NV United States

John A. Ellerton

Radiation Oncology Associates
Reno, NV United States

Caroline Chung, MD

Englewood Hospital and Medical Center
Englewood, NJ United States

Caroline Chung, MD

Indu and Raj Soin Medical Center
Beavercreek, OH United States

Bret E. Friday

Duluth Clinic Ashland
Ashland, WI United States

Alan M. Nichol

BCCA-Vancouver Cancer Centre
Vancouver, BC Canada

Hany Soliman

Odette Cancer Centre- Sunnybrook Health Sciences Centre
Toronto, ON Canada

David Roberge

CHUM - Centre Hospitalier de l'Universite de Montreal
Montreal, QC Canada

Christopher M. Reynolds

Saint Joseph Health System-Tawas City
Tawas City, MI United States

Ashley L. Sumrall

Carolinas Medical Center/Levine Cancer Institute
Charlotte, NC United States

Caroline Chung, MD

Charleston Hematology Oncology Associates PA-Saint Francis
Charleston, SC United States

Christopher E. Haberman

Memorial Health University Medical Center
Savannah, GA United States

Rakesh Gaur

Central Care Cancer Center - Garden City
Garden City, KS United States

Rakesh Gaur

Central Care Cancer Center - Great Bend
Great Bend, KS United States

Rakesh Gaur

Kansas Institute of Medicine Cancer and Blood Center
Lenexa, KS United States

Rakesh Gaur

Minimally Invasive Surgery Hospital
Lenexa, KS United States

Rakesh Gaur

Menorah Medical Center
Overland Park, KS United States

Caroline Chung, MD

Saint Luke's South Hospital
Overland Park, KS United States

John A. Ellerton

Huron Medical Center PC
Port Huron, MI United States

Rakesh Gaur

Central Care Cancer Center - Bolivar
Bolivar, MO United States

Rakesh Gaur

Centerpoint Medical Center LLC
Independence, MO United States

Caroline Chung, MD

Saint Luke's Hospital of Kansas City
Kansas City, MO United States

Rakesh Gaur

Research Medical Center
Kansas City, MO United States

Caroline Chung, MD

Saint Luke's East - Lee's Summit
Lee's Summit, MO United States

Caroline Chung, MD

Heartland Regional Medical Center
Saint Joseph, MO United States

Pamela A. Lepera

East Carolina University
Greenville, NC United States

Hui-Kuo G. Shu

Emory University Hospital/Winship Cancer Institute
Atlanta, GA United States

Caroline Chung, MD

Cleveland Clinic Akron General
Akron, OH United States

Sharad A. Ghamande

University Cancer and Blood Center LLC
Athens, GA United States

Caroline Chung, MD

Beaumont Hospital - Farmington Hills
Farmington Hills, MI United States

Bret E. Friday

Essentia Health Hibbing Clinic
Hibbing, MN United States

Garth A. Nicholas

Ottawa Hospital and Cancer Center-General Campus
Ottawa, ON Canada

Robert J. Behrens

Trinity Regional Medical Center
Fort Dodge, IA United States

Steven P. Howard

University of Wisconsin Hospital and Clinics
Madison, WI United States

Laurence Masson-Cote

Centre Hospitalier Universitaire de Sherbrooke-Fleurimont
Sherbrooke, QC Canada

Bret E. Friday

Essentia Health - Deer River Clinic
Deer River, MN United States

Bret E. Friday

Essentia Health Saint Mary's - Detroit Lakes Clinic
Detroit Lakes, MN United States

Bret E. Friday

Essentia Health - Fosston
Fosston, MN United States

Bret E. Friday

Essentia Health - Park Rapids
Park Rapids, MN United States

Bret E. Friday

Essentia Health Sandstone
Sandstone, MN United States

Yuhchyau Chen

University of Rochester
Rochester, NY United States

Bret E. Friday

Essentia Health - Jamestown Clinic
Jamestown, ND United States

Aaron P. Provenzano

WVUH-Berkely Medical Center
Martinsburg, WV United States

Aaron P. Provenzano

Camden Clark Medical Center
Parkersburg, WV United States

Bret E. Friday

Ashland Memorial Medical Center
Ashland, WI United States

Recruitment Status: Closed


Brief Description Eligibility Contact Research Team


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