Last updated on August 2018

A Study of Ramucirumab (LY3009806) Versus Placebo in Participants With Hepatocellular Carcinoma and Elevated Baseline Alpha-Fetoprotein


Brief description of study

The purpose of this study is to evaluate the safety and efficacy of ramucirumab in participants with hepatocellular carcinoma (HCC) and elevated baseline alpha-fetoprotein. Participants will be randomized to ramucirumab or placebo in a 2:1 ratio (Main Global Cohort and China Maximized Extended Enrollment {ME2} Cohort). Participants may also receive ramucirumab if eligible to be enrolled in Open-Label Expansion (OLE) Cohort.

Clinical Study Identifier: NCT02435433

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Ari Baron

Pacific Hematology and Oncology Associates
Daly City, CA United States
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Richard Finn

UCLA Medical Center
Los Angeles, CA United States
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Mark Karwal

University of Iowa Hospital
Iowa City, IA United States
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Andrew Zhu

Massachusetts General Hospital
Boston, MA United States
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Charissa Chang

Mount Sinai Medical Center
New York, NY United States
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Shubham Pant

University of Oklahoma Health Sciences Center
Oklahoma City, OK United States
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Gina Vaccaro

OREGON HEALTH and SCIENCE UNIVERSITY
Portland, OR United States
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Kurralta Park, Australia
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Woodville, Australia
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Linz, Austria
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Wien, Austria
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Brussels, Belgium
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Liege, Belgium
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Funda o PIO XII
Barretos, Brazil
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Cenantron - Centro Avan ado de Tratamento Oncol gico
Belo Horizonte, Brazil
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Associa o Hospital de Caridade Iju
Ijui, Brazil
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Porto Alegre, Brazil
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Montreal, Canada
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Toronto, Canada
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Beijing, China
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Changsha, China
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Guangdong, China
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Hefei, China
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Heilongjiang, China
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Henan, China
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Hubei, China
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Nanjing, China
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Shanghai, China
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Wu Han, China
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Brno, Czechia
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Praha 5, Czechia
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Amiens, France
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Avignon, France
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Besancon, France
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Caen, France
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Clermont-Ferrand, France
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Lyon, France
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Montpellier, France
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Nantes, France
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Pessac, France
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Rennes, France
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Saint Etienne, France
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Bayern, Germany
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Berlin, Germany
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Essen, Germany
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Frankfurt, Germany
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Hamburg, Germany
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Hannover, Germany
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Leipzig, Germany
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Magdeburg, Germany
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Mainz, Germany
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Tubingen, Germany
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Hong Kong, Hong Kong
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Kowloon, Hong Kong
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ShaTin, Hong Kong
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Tuen Mun, Hong Kong
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Haifa, Israel
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Tel Aviv, Israel
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Benevento, Italy
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Bologna, Italy
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Cremona, Italy
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Padova, Italy
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Rome, Italy
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Chuo Ku, Japan
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Fukuoka, Japan
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Fukuoka, Japan
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Iizuka, Japan
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Kanazawa, Japan
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Kashiwa, Japan
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Kyoto, Japan
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Matsuyama, Japan
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Osaka, Japan
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Shimotsuke, Japan
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Suita-shi, Japan
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Sunto-Gun, Japan
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Tokyo, Japan
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Yokohama, Japan
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Aiwu He

Georgetown University Medical Center
Washington, WA United States
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Beijing, China
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Chongqing, China
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Guangzhou, China
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Hangzhou, China
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Nanning, China
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Qingdao, China
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Shanghai, China
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Shenyang, China
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Xi'an, China
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Barretos, Brazil
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Changsha, China
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Hebei, China
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Shanghai, China
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Hong Kong, Hong Kong
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São Paulo, Brazil
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München, Germany
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Recruitment Status: Open


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