Last updated on October 2018

A Study of Ramucirumab (LY3009806) in Combination With Erlotinib in Participants With EGFR Mutation-Positive Metastatic NSCLC


Brief description of study

The main purpose of this study is to evaluate the safety and efficacy of ramucirumab in combination with erlotinib as compared to placebo in combination with erlotinib in participants with stage IV non small cell lung cancer (NSCLC) harboring an activating epidermal growth factor receptor (EGFR) mutation (Del19 and L858R). Safety and tolerability of ramucirumab in combination with erlotinib will be assessed in the first portion (Part A) before proceeding to the second portion of this study (Part B).

The purpose of Part C is to determine the efficacy and safety of ramucirumab in combination with gefitinib in previously untreated East Asian participants with EGFR mutation-positive metastatic NSCLC and of ramucirumab in combination with osimertinib in those participants whose disease progressed on ramucirumab and gefitinib and that have T790M - positive metastatic NSCLC.

Clinical Study Identifier: NCT02411448

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Keunchil Park

Samsung Medical Center
Seoul, Korea, Republic of
4.3miles
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Korea University Guro Hospital
Seoul, Korea, Republic of
4.3miles
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Seoul St. Mary's Hospital
Seoul, Korea, Republic of
4.3miles
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Seoul Municipal Boramae Hospital
Seoul, Korea, Republic of
4.3miles
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Sang-We Kim

Asan Medical Center
Songpa-gu, Korea, Republic of
9.17miles
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