Last updated on February 2019

A Study of Ramucirumab (LY3009806) in Combination With Erlotinib in Participants With EGFR Mutation-Positive Metastatic NSCLC


Brief description of study

The main purpose of this study is to evaluate the safety and efficacy of ramucirumab in combination with erlotinib as compared to placebo in combination with erlotinib in participants with stage IV non small cell lung cancer (NSCLC) harboring an activating epidermal growth factor receptor (EGFR) mutation (Del19 and L858R). Safety and tolerability of ramucirumab in combination with erlotinib will be assessed in the first portion (Part A) before proceeding to the second portion of this study (Part B).

The purpose of Part C is to determine the efficacy and safety of ramucirumab in combination with gefitinib in previously untreated East Asian participants with EGFR mutation-positive metastatic NSCLC and of ramucirumab in combination with osimertinib in those participants whose disease progressed on ramucirumab and gefitinib and that have T790M - positive metastatic NSCLC.

Clinical Study Identifier: NCT02411448

Contact Investigators or Research Sites near you

Start Over

There may be multiple sites ...

TRIO - Translational Research in Oncology-US, Inc.
Los Angeles, CA United States

There may be multiple sites ...

UCLA Medical Center
Los Angeles, CA United States

There may be multiple sites ...

Pharmatech Oncology Inc
Denver, CO United States

There may be multiple sites ...

The Queen's Medical Center
Honolulu, HI United States

There may be multiple sites ...

St. Charles Health System
Bend, OR United States

There may be multiple sites ...

Allegheny General Hospital
Pittsburgh, PA United States

There may be multiple sites ...

Hospital Universitario La Fe de Valencia
Valencia, Spain

There may be multiple sites ...

Cancer Center of Kansas
Wichita, KS United States

There may be multiple sites ...

Queens Medical Associates
Fresh Meadows, NY United States

There may be multiple sites ...

Levine Cancer Institute- Carolinas Medical Center
Charlotte, NC United States

There may be multiple sites ...

Cross Cancer Institute
Edmonton, AB Canada

There may be multiple sites ...

CHU Albert Michallon
Grenoble, France

There may be multiple sites ...

CHRU de Lille-H pital Albert Calmette
Lille, France

There may be multiple sites ...

Centre hospitalier universitaire Lapeyronie
Montpellier Cedex 5, France

There may be multiple sites ...

APHP-H pital Europ en Georges Pompidou
Paris, France

There may be multiple sites ...

CHU la Miletrie
Poitiers, France

There may be multiple sites ...

Klinik Schillerh he
Gerlingen, Germany

There may be multiple sites ...

Thoraxklinik Heidelberg gGmbH
Heidelberg, Germany

There may be multiple sites ...

St dtisches Krankenhaus Martha-Maria Halle-D lau gGmbH
Halle (Saale), Germany

There may be multiple sites ...

Klinikum Chemnitz GmbH
Chemnitz, Germany

There may be multiple sites ...

HELIOS Klinikum Emil von Behring
Berlin, Germany

Haralabos Kalofonos

University General Hospital of Patras
Patras, Greece

Konstantinos N Syrigos

SOTIRIA General Hospital
Athens, Greece

There may be multiple sites ...

Queen Mary Hospital
Hong Kong, Hong Kong

There may be multiple sites ...

Queen Elizabeth Hospital
Kowloon, Hong Kong

There may be multiple sites ...

Azienda per l'Assistenza Sanitaria n 5 "Friuli Occidentale"
Pordenone, Italy

There may be multiple sites ...

Azienda Ospedaliero - Universitaria S. Luigi Gonzaga
Orbassano, Italy

There may be multiple sites ...

IRCCS Ospedale Oncologico di Bari
Bari, Italy

There may be multiple sites ...

Policlinico S. Orsola Malpighi - Universita di Bologna
Bologna, Italy

There may be multiple sites ...

IRCCS Ospedale San Raffaele
Milano, Italy

There may be multiple sites ...

Istituto Oncologico Veneto
Padova, Italy

Ki Hyeong Lee

Chungbuk National University Hospital
Cheongju-si, Korea, Republic of

There may be multiple sites ...

Saint Vincent Hospital
Suwon, Korea, Republic of

There may be multiple sites ...

Ajou University Hospital
Suwon, Korea, Republic of

There may be multiple sites ...

Gyeong-Sang National University Hospital
Jin-ju-si, Korea, Republic of

Keunchil Park

Samsung Medical Center
Seoul, Korea, Republic of

There may be multiple sites ...

Korea University Guro Hospital
Seoul, Korea, Republic of

There may be multiple sites ...

Ulsan University Hospital
Ulsan, Korea, Republic of

Sang-We Kim

Asan Medical Center
Songpa-gu, Korea, Republic of

There may be multiple sites ...

Seoul St. Mary's Hospital
Seoul, Korea, Republic of

There may be multiple sites ...

Seoul Municipal Boramae Hospital
Seoul, Korea, Republic of

There may be multiple sites ...

S.C. MedisProf SRL
Cluj-Napoca, Romania

There may be multiple sites ...

Institutul Oncologic Dr Trestioreanu Bucuresti
Bucuresti, Romania

There may be multiple sites ...

Hospital Fundacion Son Llatzer
Palma de Mallorca, Spain

There may be multiple sites ...

Institut Catala d'Oncologia
L'Hospitalet de Llobregat, Spain

There may be multiple sites ...

Hospital Universitario Quiron Madrid
Pozuelo de Alarcon, Spain

There may be multiple sites ...

Clinica Universitaria De Navarra
Pamplona, Spain

There may be multiple sites ...

Hospital Universitari Vall d'Hebron
Barcelona, Spain

There may be multiple sites ...

Hospital Universitario 12 de Octubre
Madrid, Spain

There may be multiple sites ...

Hospital Universitario Virgen del Rocio
Sevilla, Spain

There may be multiple sites ...

Hospital Universitario Nuestra Se ora de Valme
Sevilla, Spain

There may be multiple sites ...

Chang Gung Memorial Hospital - Kaohsiung
Kaohsiung City, Taiwan

There may be multiple sites ...

China Medical University Hospital
Taichung City, Taiwan

Gee-Chen Chang

Taichung Veterans General Hospital
Taichung, Taiwan

There may be multiple sites ...

National Cheng Kung University Hospital
Tainan, Taiwan

Jin-Yuan Shih

National Taiwan University Hospital
Taipei City, Taiwan

There may be multiple sites ...

MacKay Memorial Hospital
Taipei City, Taiwan

There may be multiple sites ...

Baskent Adana Educational Hospital
Adana, Turkey

There may be multiple sites ...

Trakya University Faculty of Medicine
Edirne, Turkey

There may be multiple sites ...

Ege University Faculty of Medicine
Izmir, Turkey

There may be multiple sites ...

Inonu University Medical Faculty
Malatya, Turkey

There may be multiple sites ...

Royal Marsden NHS Trust
London, United Kingdom

There may be multiple sites ...

Charing Cross Hospital
Chelsea, United Kingdom

There may be multiple sites ...

Nottingham City Hospital
Nottingham, United Kingdom

HIDEO SAKA

Nagoya Medical Center
Nagoya, Japan

There may be multiple sites ...

Aichi Cancer Center Hospital
Nagoya, Japan

There may be multiple sites ...

National Cancer Center Hospital East
Kashiwa, Japan

There may be multiple sites ...

National Hospital Organization Shikoku Cancer Center
Matsuyama, Japan

There may be multiple sites ...

Kurume University Hospital
Kurume, Japan

There may be multiple sites ...

National Hospital Organization Asahikawa Medical Center
Asahikawa, Japan

There may be multiple sites ...

Hyogo Cancer Center
Akashi, Japan

There may be multiple sites ...

Hyogo Prefectual Amagasaki General Medical Center
Amagashiki City, Japan

There may be multiple sites ...

National Hospital Organization Himeji Medical Center
Himeji, Japan

There may be multiple sites ...

Foundation for Biomedical Research and innovation
Kobe, Japan

There may be multiple sites ...

Kobe City Medical Center General Hospital
Kobe, Japan

There may be multiple sites ...

Kanazawa University Hospital
Kanazawa, Japan

There may be multiple sites ...

Kanagawa Cardiovascular and Respiratory Center
Yokohama, Japan

There may be multiple sites ...

Kanagawa Cancer Center
Yokohama, Japan

There may be multiple sites ...

Sendai Kousei Hospital
Sendai, Japan

There may be multiple sites ...

Osaka Habikino Medical Center
Habikino, Japan

There may be multiple sites ...

Kansai Medical University Hospital
Hirakata, Japan

There may be multiple sites ...

Kishiwada City Hospital
Kishiwada, Japan

There may be multiple sites ...

Kindai University Hospital
Osaka Sayama-shi, Japan

There may be multiple sites ...

National Hospital Organization Kinki-Chuo Chest Medical Cent
Sakai, Japan

There may be multiple sites ...

Saitama Cancer Center
Kita-Adachi, Japan

There may be multiple sites ...

Shizuoka Cancer Center
Sunto-Gun, Japan

There may be multiple sites ...

Juntendo University Hospital
Bunkyo-ku, Japan

There may be multiple sites ...

Nippon Medical School Hospital
Bunkyo-Ku, Japan

There may be multiple sites ...

Tokyo Met Cancer & Infectious Diseases Center Komagome Hp
Bunkyo-ku, Japan

There may be multiple sites ...

National Cancer Center Hospital
Chuo-Ku, Japan

There may be multiple sites ...

St. Lukes International Hospital
Chuo-Ku, Japan

There may be multiple sites ...

The Cancer Institute Hospital of JFCR
Koto-ku, Japan

There may be multiple sites ...

Yamaguchi-Ube Medical Center
Ube, Japan

There may be multiple sites ...

Chiba University Hospital
Chiba, Japan

There may be multiple sites ...

National Hospital Organization Kyushu Medical Center
Fukuoka, Japan

There may be multiple sites ...

Kyushu Cancer Center
Fukuoka, Japan

There may be multiple sites ...

Kyushu University Hospital
Fukuoka, Japan

There may be multiple sites ...

Kyoto University Hospital
Kyoto, Japan

There may be multiple sites ...

Nagasaki University Hospital
Nagasaki, Japan

There may be multiple sites ...

Niigata University Medical & Dental Hospital
Niigata, Japan

There may be multiple sites ...

Niigata Cancer Center Hospital
Niigata, Japan

There may be multiple sites ...

Okayama University Hospital
Okayama, Japan

There may be multiple sites ...

Osaka City General Hospital
Osaka, Japan

There may be multiple sites ...

Osaka International Cancer Institute
Osaka, Japan

There may be multiple sites ...

Osaka City University Hospital
Osaka, Japan

There may be multiple sites ...

Wakayama MedicaL University Hospital
Wakayama, Japan

There may be multiple sites ...

Kliniken der Stadt K ln gGmbH Klinikum K ln-Merheim
Köln, Germany

There may be multiple sites ...

LungenClinic Grosshansdorf
Großhansdorf, Germany

Yu-Feng Wei

E-DA Hospital
Kaohsiung, Taiwan

Chao-Hua Chiu

Taipei Veterans General Hospital
Taipei, Taiwan

Recruitment Status: Closed


Brief Description Eligibility Contact Research Team


Receive Emails About New Clinical Trials!

Sign up for our FREE service to receive email notifications when clinical trials are posted in the medical category of interest to you.