Last updated on December 2016

Comparison of Fimasartan Versus Amlodipine Therapy on Carotid PlaquE Inflammation

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Inflammation Plaque | Coronary Disease | Atherosclerotic | Renin-Angiotensin System
  • Age: Between 18 - 100 Years
  • Gender: Male or Female
  • Other:
    Men or Women at least 18 years of age inclusive
    Patients with acute coronary syndromes or unstable angina pectoris
    Hypertension or blood pressure more than 140/90mmHg
    FDG PET/CT shows at least 1 hot uptakes at carotid and or ascending aorta
    The patient or guardian agrees to the study protocol and the schedule of clinical and
    FDG PET/CT follow-up, and provides informed, written consent, as approved by the
    appropriate Institutional Review Board/Ethical Committee of the respective clinical

You may not be eligible for this study if the following are true:

  • Patients treated with carotid endarterectomy or stent placement
    Chronic disease requiring treatment with oral, intravenous, or intra-articular
    corticosteroids (use of topical, inhaled, or nasal corticosteroids is permissible).
    Untreated hyperthyroidism, or hypothyroidism
    Any clinically significant abnormality identified at the screening visit, physical
    examination, laboratory tests, or electrocardiogram which, in the judgment of the
    Investigator, would preclude safe completion of the study.
    Evidence of congestive heart failure, or left ventricular ejection fraction < 40%.
    Significant renal disease manifested by serum creatinine > 2.0mg/dL, or creatinine
    clearance of < 40 ml/min (by Cockcroft-Gault method).
    Hepatic disease or biliary tract obstruction, or significant hepatic enzyme elevation
    (ALT or AST > 3 times upper limit of normal).
    History of adult asthma manifested by bronchospasm in the past 6 months, or currently
    taking regular anti-asthmatic medication(s).
    Unwillingness or inability to comply with the procedures described in this protocol.
    Patient's pregnant or breast-feeding or child-bearing potential.
    Type I Diabetes

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

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