Last updated on August 2015

Initiation of Non- Invasive Ventilation at Home Versus Hospital Among Patients With Overlap Syndrome

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Overlap Syndrome
  • Age: Between 18 - 80 Years
  • Gender: Male or Female
  • Other:
    Major patients, of less than 80 years
    Patients with chronic respiratory failure within a Overlap syndrome ( defined by the
    coexistence of COPD and OAS ) in stable situation (no exacerbation for at least 4
    weeks) , indication for a NIV treatment
    OAS confirmed by polysomnography according to the standards of the American Academy
    of Sleep Medicine ( AASM ) with an AHI> 15, the central apneas are tolerated if < 20%
    COPD defined by obstruction of the air flow : VEMS/CVF <70 % and VEMS <80% of the
    average value predicted
    Started criteria of NIV: chronic respiratory failure within an Overlap Syndrome and
    PaCO2 > 45 mmHg (at rest on room air ) and / or medium PtCO2 > 50 mmHg
    Patient informed of the study and who signed an informed consent

You may not be eligible for this study if the following are true:

  • Patients already treated for OAS in the year
    Patient tracheotomised
    Other diseases with respiratory involvement : neuromuscular disease , restrictive
    disease of the chest with CPT <80% , apnea syndrome pure central sleep ( central
    apnea are tolerated if < 20% )
    Lung cancer within the last 5 years
    Uncontrolled psychic diseases
    Acute respiratory failure requiring NIV , going back a month
    Clinical situation requiring prolonged hospitalization
    Patients with no opportunity to understand and follow instructions
    Refusal to participate in the study
    Lack of insurance coverage
    Pregnant and / or nursing

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

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