Last updated on March 2019

Study of Lifileucel ( LN-144) Autologous Tumor Infiltrating Lymphocytes in the Treatment of Patients With Metastatic Melanoma


Brief description of study

Prospective, interventional multicenter study evaluating adoptive cell therapy (ACT) with Lifileucel infusion (LN-144) followed by interleukin 2 (IL-2) after a nonmyeloablative lymphodepletion (NMA-LD) preparative regimen.

Detailed Study Description

Lifileucel is an autologous adoptive cell transfer therapy that utilizes a TIL manufacturing process, as originally developed by the NCI, for the treatment of patients with metastatic melanoma. The adoptive cell transfer therapy used in this study involves patients receiving a lymphocyte depleting preconditioning regimen, prior to infusion of autologous TIL, followed by the administration of a regimen of IL-2.

Clinical Study Identifier: NCT02360579

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Iovance Biotherapeutics Clinical Inquiries

Iovance Investigative Site
Miami Beach, FL United States
4.22miles
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Recruitment Status: Open


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