Effects of Sitaglpitin on Endothelial Function During the OGTT in T2DM

  • STATUS
    Not Recruiting
  • participants needed
    30
  • sponsor
    Dokkyo Medical University
Updated on 21 January 2021
Investigator
Yoshimasa Aso, MD
Primary Contact
Dokkyo Medical University (6.5 mi away) Contact
fasting
antihypertensive drugs
sitagliptin
hypoglycemic agents
glimepiride

Summary

To investigate whether single administration of sitaglitpin can restore acute endothelial dysfunction and ameliorate impaired increase of the number of endothelial progenitor cells (EPCs) after oral glucose loading in patients with T2DM.

To compare the effect of sitagliptin and glimepiride on endothelial function evaluated by flow-mediated vasodilatation (FMD) and the number of circulating EPCs in patients with T2DM.

Description

Acute and chronic improvement of endothelial function is expected through the pleiotropic effect of DPP-4 inhibitors. A randomized, prospective, open-labeled, parallel design. The duration of treatments with sitagliptin or glimepiride is 12 weeks. The number of study centers is a single (Dokkyo Medical University Hospital). Participants will be randomized into the two treatment groups; (a) 50mg sitagliptin (N=15) and (b) 1mg glimepiride (N=15).

Anti-Hyperglycemic effect is expected to be similar according to our study

Details
Condition NIDDM
Treatment Sitagliptin, Glimepiride, dieting
Clinical Study IdentifierNCT02301806
SponsorDokkyo Medical University
Last Modified on21 January 2021

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