Last updated on December 2018

Allergy to Neuromuscular Blocking Agents and Pholcodine Exposure


Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Neuromuscular Blocking Agents Anaphylaxis
  • Age: Between 2 - 100 Years
  • Gender: Male or Female

Inclusion Criteria:

  • Male or female, age 2 years old.
  • Referred to anaesthesia-allergy consultation within (approximately) 6 to 12 weeks of occurrence of peranaesthetic anaphylactic reaction during anaesthesia with administration of NMBAs (only for case patient).
  • Having given his/her consent (or the 2 parents consent for minors).
  • Affiliated with a social security scheme or dependent.
  • Able to answer a medicinal product intake questionnaire
  • In a clinical condition compatible with skin tests (no skin disease or psychiatric illness, etc.) (only for case patient)
  • Having stopped any anti-histamine treatment at least 8 days previously (only for case patient).
  • With positive skin test for the suspected NMBA (ony for case patient).
  • Patient anaesthetised in a control recruitment centre (only for control patients)
  • Having undergone anaesthesia with NMBA injection, without onset of peranaesthetic anaphylactic reaction whatever his medical history (only for control patients)

Exclusion Criteria:

  • Patients who have refused, or are unable to give their consent
  • Patients who have had negative control skin tests
  • Anaphylaxis suspected to be related to other drugs given on induction of anaesthesia, eg. antibiotics
  • Having presented with anaphylactic reaction during a previous anaesthesia without NMBA injection
  • Pregnant females

Recruitment Status: Open


Brief Description Eligibility Contact Research Team


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