Last updated on February 2018

Efficacy and Safety of Everolimus and (STZ-5FU) Given One Upfront the Other Upon Progression in Advanced pNET

Brief description of study

The purpose of this study is to elucidate which sequence of streptozotocin (STZ) based chemotherapy and the mammalian Target of Rapamycin (mTOR) inhibitor, everolimus, gives better results in terms of second Progression Free Survival (PFS) in well differentiated and advanced pancreatic NETs.

Detailed Study Description

STZ based chemotherapy, STZ-5FU, is the actual standard of care for advanced pancreatic Neuroendocrine tumours (pNETS) in the European Union. Everolimus has been recently approved for its use in advanced pNETs by the Food and Drug Administration (FDA) and in Europe by the European Medical Agency (EMA).

A randomized study is needed to have a clear knowledge about the best sequence for its administration; this is, before or after palliative chemotherapy.

There may or may not be any benefits from giving first each other treatment of the study. The information obtained from this study will help the physician improve the treatment and management of patients with advanced pNET.

Clinical Study Identifier: NCT02246127

Contact Investigators or Research Sites near you

Start Over

Morten Ladekarl

Aarhus Aarhus University Hospital NET Centre (AUH-NET)
Aarhus, Denmark
  Connect »

Ulrich Peter Knigge

Rigshospitalet NET CoE, University of Copenhagen
Copenhagen, Denmark
  Connect »

Derk Jan de groot

UMCG / University of Groningen
Groningen, Denmark
  Connect »

Judith de Vos-Geelen

Maastricht UMC
Maastricht, Denmark
  Connect »

Lene Vestermark

Odense University Hospital
Odense, Denmark
  Connect »

Jean-Philippe Metges

Brest Hopital Augustin Morvan, Institut de Cancero-Hemato
Brest, France
  Connect »

Philippe Ruszniewski

Clichy Neuroendocrine Tumor (NET) Center Hopital Beaujon
Clichy, France
  Connect »

Eric Baudin

Institut Gustave-Roussy
Villejuif, France
  Connect »

Bernard Goichot

H pitaux Universitaires de Strasbourg H pital de Hautepierre
Strasbourg, France
  Connect »

Francois-Xavier Caroli-Bosc

UTTIOM Unit Transversale de Th rapeutiques Innovantes en Oncologie M dicale CHU Angers
Anger, France
  Connect »

Denis Smith

University Hospital of Bordeaux H pital Saint-Andr
Bordeaux, France
  Connect »

Thomas Walter

H pital Edouard Herriot
Lyon, France
  Connect »

Jean-Francois Seitz

H pital La Timone
Marseille, France
  Connect »

Dieter Hörsch

Bad Berka ChA Klinik f r Innere Medizin
Bad Berka, Germany
  Connect »

Frank Ulrich Pape

Berlin Charit Universit tsmedizin
Berlin, Germany
  Connect »

Sebastian Krug

UKM Facharzt f r Innere Medizin Gastroenterologie, Onkologische Gastroenterologie (DGVS)
Halle, Germany
  Connect »

Joerg Schrader

Medizinische Klinik und Poliklinik , Universit tsklinikum Hamburg-Eppendorf
Hamburg, Germany
  Connect »

Peter Malfertheiner

Magdeburg Universit tsklinikum Magdeburg A. . R
Magdeburg, Germany
  Connect »

Mathias Weber

Mainz Universit tsmedizin
Mainz, Germany
  Connect »

Anja Rinke

Marburg Universit tsklinikum Giessen und Marburg GmbH
Marburg, Germany
  Connect »

Carlo Carnaghi

Istituto Europeo di Oncologia- IRCCS
Milano, Italy
  Connect »

Salvatore Tafuto

Istituto Nazionale Tumori (Fondazione G Pascale)
Napoli, Italy
  Connect »

Heinz-Josef Klümpen

Amsterdam Academic Medical Center
Amsterdam, Netherlands
  Connect »

Paula Jimenez Fonseca

Hospital Central de Asturias
Oviedo, Spain
  Connect »

Jose Luis Manzano

Hospital Universitario Germans Trias i Pujol
Badalona, Spain
  Connect »

Alexander Teule

Instituto Catal n de Oncolog a de Hospitalet
L'Hospitalet de Llobregat, Spain
  Connect »

Marta Martin

Hospital de la Santa Creu i Sant Pau
Barcelona, Spain
  Connect »

Jaume Capdevila

Hospital Universitario Vall d'Hebron
Barcelona, Spain
  Connect »

Rocío García-Carbonero

Hospital Universitario 12 de Octubre
Madrid, Spain
  Connect »

Marta Benavent

Hospital Universitario Virgen del Roc o
Sevilla, Spain
  Connect »

Barbro Eriksson

University Hospital
Uppsala, Sweden
  Connect »

Nicholas Simon Reed

West of Scotland Cancer Centre Gartnavel General Hospital
Beatson, United Kingdom
  Connect »

Birgit Cremer

K ln Universit tsklinikum K ln (A R)
Köln, Germany
  Connect »

Christoph Josef Auernhammer

Interdisciplinary Center of Neuroendocrine Tumors of the GastroEnteroPancreatic System (GEPNET-KUM) at the University of Munich
München, Germany
  Connect »

Alexander von Werder

Medizin II am Klinik und Poliklinik rechts der Isar
München, Germany
  Connect »

Maria Isabel Sevilla

HCU Virgen de la Victoria
Málaga, Spain
  Connect »

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

Receive Emails About New Clinical Trials!

Sign up for our FREE service to receive email notifications when clinical trials are posted in the medical category of interest to you.