A Phase 2 Study of CPI-0610 With and Without Ruxolitinib in Patients With Myelofibrosis

  • days left to enroll
  • participants needed
  • sponsor
    Constellation Pharmaceuticals
Updated on 30 May 2022
platelet count
myelodysplastic syndromes
acute leukemia
myeloproliferative disorder
growth factor
blast cells
janus kinase inhibitor
myelodysplastic/myeloproliferative neoplasms


Phase 1 Part (Complete): Open-label, sequential dose escalation study of CPI-0610 in patients with previously treated Acute Leukemia, Myelodysplastic Syndrome, Myelodysplastic/Myeloproliferative Neoplasms, and Myelofibrosis.

Phase 2 Part: Open-label study of CPI-0610 with and without Ruxolitinib in patients with Myelofibrosis.

CPI-0610 is a small molecule inhibitor of bromodomain and extra-terminal (BET) proteins.

Condition Myelofibrosis, Leukemia, Myelocytic, Acute, Myelodysplastic/Myeloproliferative Neoplasm, Myelodysplastic Syndrome (MDS), Preleukemia, Primary Myelofibrosis, Myeloproliferative Disorders, Bone Marrow Disease, Hematological Disease, Precancerous Conditions, Neoplasms, Leukemia, Neoplasms by Histologic Type, Essential Thrombocytosis
Treatment Ruxolitinib, CPI-0610
Clinical Study IdentifierNCT02158858
SponsorConstellation Pharmaceuticals
Last Modified on30 May 2022


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