Last updated on February 2018

Efficacy and Safety of Amantadine HCl Extended Release Tablets to Treat Parkinson's Disease Patients With Levodopa Induced Dyskinesia.


Brief description of study

Amantadine has been used for many years as a treatment for Parkinson's disease. It has been reported in the literature to effectively treat the motor complications of levodopa, especially dyskinesia, but it must be given 2 to 4 times a day. The purpose of this multi-center, randomized, double-blind, parallel-group, 16 week study is to compare the efficacy and safety of two different dose levels of Amantadine Extended Release Tablets to placebo for the treatment of levodopa induced dyskinesia in patients with Parkinson's disease. The dose will be given once a day in the morning so that amantadine concentrations are maintained throughout the day for treating the levodopa induced dyskinesia, but will be lower during the night, potentially reducing the negative impact of amantadine on sleep.

Clinical Study Identifier: NCT02153645

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Angela Dentiste, MBA

Tucson, AZ United States
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Angela Dentiste, MBA

Fountain Valley, CA United States
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Angela Dentiste, MBA

Irvine, CA United States
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Angela Dentiste, MBA

Pasadena, CA United States
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Angela Dentiste, MBA

Reseda, CA United States
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Angela Dentiste, MBA

Ventura, CA United States
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Angela Dentiste, MBA

Boulder, CO United States
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Angela Dentiste, MBA

Hollywood, FL United States
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Angela Dentiste, MBA

Miami, FL United States
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Angela Dentiste, MBA

North Palm Beach, FL United States
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Angela Dentiste, MBA

Tampa, FL United States
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Angela Dentiste, MBA

Chicago, IL United States
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Angela Dentiste, MBA

Indianapolis, IN United States
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Angela Dentiste, MBA

Baton Rouge, LA United States
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Angela Dentiste, MBA

Ann Arbor, MI United States
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Angela Dentiste, MBA

Summit, NJ United States
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Angela Dentiste, MBA

Brooklyn, NY United States
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Angela Dentiste, MBA

Manhasset, NY United States
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Angela Dentiste, MBA

Patchogue, NY United States
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Angela Dentiste, MBA

Raleigh, NC United States
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Angela Dentiste, MBA

Columbus, OH United States
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Angela Dentiste, MBA

Round Rock, TX United States
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Angela Dentiste, MBA

Orem, UT United States
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Angela Dentiste, MBA

Kirkland, WA United States
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Angela Dentiste, MBA

Clermont-Ferrand, France
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Angela Dentiste, MBA

Hindenburgdamm, Germany
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Recruitment Status: Open


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