Last updated on March 2018

AURORA: Aiming to Understand the Molecular Aberrations in Metastatic Breast Cancer.

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Metastatic Breast Cancer
  • Age: Between 18 - 100 Years
  • Gender: Male or Female

Inclusion Criteria:

  1. Women or men with metastatic or locally relapsed breast cancer manageable with systemic therapy
  2. Eastern Cooperative Oncology Group (ECOG) Performance Status 0 or 1.
  3. Written informed consent prior to enrollment into the program.
  4. Patient aged 18 years
  5. Patient agrees to provide archived primary tumor tissue
  6. Patient agrees to provide newly collected metastatic lesions tissue samples (archived material up to 6 months is allowed provided both Formalin Fixed Paraffin Embedded (FFPE) block and Frozen Tissue are available and were collected from the same lesion at the same time)
  7. Patient agrees to provide blood samples

Exclusion Criteria:

  1. The patient has received more than 1 line of systemic therapy (any type) in the metastatic setting
  2. Patients who have received prior palliative radiotherapy to the only site that is accessible to biopsy
  3. Patients with bone-only metastatic disease
  4. Patients with brain-only metastatic disease, unless surgical excision is planned (in which case tissue will be collected for AURORA purpose)
  5. Known presence of severe hematopoietic, renal, and/or hepatic dysfunction (according to the local PI)
  6. Platelet count<100 000/mm3, INR>1.5 (international normalized ratio; blood clotting time) , Albumin<30
  7. Previous or current malignancies of other histologies within the last 5 years, with the exception of in situ carcinoma of the cervix, and adequately treated basal cell or squamous cell carcinoma of the skin
  8. Any anti-VEGF (vascular endothelial growth factor) or anti-VEGFR (vascular endothelial growth factor receptor) treatment administered less than 4 weeks before new biopsy procedure or no appropriate wash-out period for patients on anticoagulation therapy

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

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