Last updated on January 2019

Trial Evaluating 3-year Disease Free Survival in Patients With Locally Advanced Rectal Cancer Treated With Chemoradiation Plus Induction or Consolidation Chemotherapy and Total Mesorectal Excision or Non-operative Management


Brief description of study

The study is designed to test the hypothesis that patients with Locally advanced rectal cancer ( LARC) treated with Total neoadjuvant therapy (TNT) and Total mesorectal excision (TME) or Non-operative management (NOM) will have an improved 3-year disease-free survival (DFS) compared to patients with similar tumors treated with Chemoradiation therapy (CRT), Total mesorectal excision (TME) and Adjuvant chemotherapy (ACT).

Clinical Study Identifier: NCT02008656

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St. Joseph Hospital

Orange, CA United States
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John Muir Health

Walnut Creek, CA United States
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University of Colorado

Aurora, CO United States
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Cleveland Clinic Florida

Weston, FL United States
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University of Chicago

Chicago, IL United States
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University of Michigan

Northville, MI United States
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CHI Heath Bergan Mercy

Omaha, NE United States
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Cleveland Clinic

Cleveland, OH United States
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University of Virginia

Charlottesville, VA United States
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Washington Hospital Center

Washington, WA United States
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Recruitment Status: Open


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