Phase I Dose Escalation Pan-FGFR (Fibroblast Growth Factor Receptor) Inhibitor

  • STATUS
    Recruiting
  • participants needed
    168
  • sponsor
    Bayer
Updated on 7 November 2020
tyrosine
measurable disease
growth factor
lung cancer
bone marrow procedure
solid tumor
solid neoplasm
bladder cancer

Summary

- This is the first study where BAY1163877 is given to humans. Impact of the study is to evaluate if patients with advanced solid cancers show advanced clinical benefit under the treatment with the pan FGFR inhibitor. Patients (all comers) will receive the study drug treatment in a dose-escalation scheme (no placebo group) to determine the safety, tolerability and maximum tolerated dose (MTD) of BAY1163877. The relative bioavailability of liquid service formulation and tablets will be determined. - After the MTD is defined patients with solid tumors (all comers), lung cancer (lung adenocarcinoma & squamous non-small cell lung cancer), head and neck cancer or bladder cancer will be enrolled according to their FGFR expression profile (biomarker stratification). - The study will also assess the pharmacokinetics, biomarker status, pharmacodynamic parameters and tumor response of BAY1163877. - BAY1163877 will be given twice daily as oral application. Treatment will be stopped if the tumor continues to grow, if side effects, which the patient cannot tolerate, occur or if the patient decides to exit treatment.

Details
Condition Non-Small Cell Lung Cancer, Cancer, bladder cancer, Transitional cell carcinoma
Treatment BAY1163877
Clinical Study IdentifierNCT01976741
SponsorBayer
Last Modified on7 November 2020

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