Last updated on June 2015

Eltrombopag for Enhancing Platelet Engraftment in Pediatric Patients Undergoing Cord Blood Transplantation


Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Pediatric Patients Undergoing Allogeneic Cord Blood Transplantation.
  • Age: Between 1 - 18 Years
  • Gender: Male or Female
  • Other:
    Patient ≥ 1 year and < 18 years old.
    Patients receiving unmanipulated single or double UCB allogeneic grafts.
    Malignant and non malignant indications for transplantation.
    Myeloablative and reduced intensity conditioning regimens.
    Patients must meet all other pre-transplantation criteria of the transplantation
    center including acceptable tests of heart, liver, kidney, and lung function
    (standard screening for transplantation per PI, and co-investigators).
    Written informed must be obtained from the patient's guardian, and accompanying
    informed assent from the patient for children over 6 years old.
    Able to comply with study protocol.

You may not be eligible for this study if the following are true:

  • Indications for transplantation
    Patients with primary myelofibrosis.
    French-American-British classification (FAB)M7 acute myeloid leukemia. Acute
    leukemia secondary to a myeloproliferative neoplasm.
    Patients with persistent acute leukemia (>5% bone marrow blasts) at the time of
    transplantation.
    Patients with prior thromboembolic event. Patients with previous catheter related
    thrombosis will be eligible if more than 3 months elapsed.
    Hypersensitivity to eltrombopag.
    Liver enzymes abnormalities:
    Alanine aminotransferase (ALT) levels > 3 times the upper limit of normal (ULN) or serum
    bilirubin > 1.5 ULN (unless due to Gilbert's syndrome or hemolytic bilirubin).

Recruitment Status: Open


Brief Description Eligibility Contact Research Team


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