One standard way of giving radiation is to combine external beam treatments with
internal brachytherapy treatments, which involve short-range radiation therapy that
gives a high dose of radiation directly to a cancer or to the area where cancer cells
Brachytherapy is done by placing hollow implant device(s) into the area to be treated
and then moving a radiation source into each. The type of device depends on the type of
cancer and the site to be treated. These devices can range from hollow applicators and
needles to balloon-like equipment.
To evaluate the quality of the brachytherapy procedure at the National Institutes of
Health s Radiation Oncology Branch.
Patients with cancer who could potentially benefit from high-dose brachytherapy as part
of their treatment.
In conjunction with their existing treatment, patients will be treated with high-dose
brachytherapy as determined appropriate for their particular type of cancer and cancer
Each treatment will take place in the Radiation Oncology Clinic.
If the patient does not have implant devices, the clinic staff will insert them and
check their placement through a computed tomography (CT) scan.
The calculations to determine the appropriate brachytherapy dose will take a few hours;
the brachytherapy treatment itself will take between 10 and 30 minutes.
The number of brachytherapy treatments will vary according to the individual needs and
requirements of each type of cancer and each patient.
Patients will return to the Radiation Oncology Clinic for followup visits at 1, 3, 6, 9,
and 12 months after the completion of radiation therapy. Followup evaluations will
include a medical history and physical examination, assessment of any side effects of
radiation therapy, and a repeat of any imaging (i.e., CT, MRI, X-ray) that was done at
baseline to evaluate the tumor response.
High dose rate brachytherapy (HDR) is a challenging technique utilized in many
malignancies in order to deliver a high dose of radiation therapy to a tumor in a
conformal fashion with a rapid dose fall-off with the objective of sparing normal
HDR therapy has been targeted to particular subsites as an integral part of either
definitive management or palliation for malignancy-related symptoms.
The primary objective is to determine the quality of high dose rate brachytherapy
implants performed in the radiation oncology branch. An implant will be adequate if 90%
of the GTV receives 90% of the dose prescribed and 80% of the CTV receives 85% of the
prescribed dose. An implant will be inadequate if the above dose limitations are not
To evaluate local control and late toxicity rates following brachytherapy at the NCI ROB
To increase the flow of oncology participants requiring brachytherapy to the NCI ROB, as
these participants lend themselves to special study and have unique educational value
for the purpose of educating nurses, medical students, residents, physicists, clinical
fellows, and physicians.
-Participants with cancer who could potentially benefit from the use of high dose rate
brachytherapy as a component of their treatment.
Participants will undergo appropriate work-up and clinical evaluation to determine if
high-dose brachytherapy would be beneficial in either primary treatment or palliation of
their disease. Participants will be treated with high-dose brachytherapy appropriately
sequenced with other modalities in their treatment regimen. This treatment will be
administered in accordance with standard radiation oncology practice and per the ABS
(American Brachytherapy Society) guidelines.
The participant s disease status and toxicity outcomes will be documented for a 12-month
period at 3-months intervals.
Cervical Cancer, Endometrial Cancer, Esophageal Cancer, Prostate Cancer, Biliary Cancer
If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.
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