Last updated on May 2018

Campath/Fludarabine/Melphalan Transplant Conditioning for Non-Malignant Diseases


Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Metabolic disorder | Non-malignant Disorders | Hematologic | Immune | Hemoglobinopathy | or Bone Marrow Disorders
  • Age: - 20 Years
  • Gender: Male or Female

Inclusion Criteria:

Stratum 1: Patient must have a hemoglobinopathy receiving a matched related transplant with bone marrow or peripheral blood stem cells.

Stratum 2: Patient must have thalassemia receiving an unrelated donor transplant with bone marrow or umbilical cord blood stem cells.

Stratum 3: Patient must have a hemoglobinopathy receiving a minimally mismatched unrelated donor transplant with bone marrow or single or double umbilical cord blood product.

Stratum 4: Patient must have a non-malignant disorder (excluding hemoglobinopathy) receiving a minor mismatched unrelated donor transplant with bone marrow or single or double umbilical cord blood product.

All strata:

  • Recipient age < 21 years
  • Lansky/Karnofsky >/= 40
  • Adequate pulmonary, renal, liver, and other organ function as defined in protocol
  • Negative pregnancy test
  • Adequate total nucleated cell or CD34+ dose of product as defined in protocol
  • If sickle cell, Hemoglobin S <45%

Exclusion Criteria:

  • HIV positive
  • Invasive infection
  • Pregnancy/lactating

Recruitment Status: Open


Brief Description Eligibility Contact Research Team


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