Erlotinib and Docetaxel in Patients With Locally Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) After Failure of One Chemotherapy Regimen

  • STATUS
    Recruiting
  • participants needed
    70
  • sponsor
    Hospital Arnau de Vilanova
Updated on 7 November 2020
platelet count
metastasis
neutrophil count
erlotinib
docetaxel
cancer chemotherapy
stage iv non-small cell lung cancer
kidney function test
secondary malignant neoplasm of liver

Summary

Erlotinib has demonstrated efficacy as a single agent in patients with NSCLC and the addition of erlotinib to chemotherapy has not achieved better results in the general population. However, several preclinical and phase I studies have shown that a sequential treatment of erlotinib and chemotherapy could avoid a possible negative interaction between both drugs when administrated concomitantly, and therefore, it could improve the benefit of the combination therapy. This study will investigate if the intermittent treatment of a chemotherapy drug, such as docetaxel, with erlotinib could achieve a clinical benefit.

Details
Condition Non-Small Cell Lung Cancer
Treatment Erlotinib, Docetaxel and Erlotinib
Clinical Study IdentifierNCT00908336
SponsorHospital Arnau de Vilanova
Last Modified on7 November 2020

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