Last updated on December 2009

Implications of Amyloid Pathology


Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Alzheimer's Disease
  • Age: Between 60 - 90 Years
  • Gender: Male or Female
  • Other:
    Age range from 60 to 90 years
    Clinical Dementia Rating (CDR) Score of 0
    Mini Mental State Exam of 27-30
    A study partner who can answer questions pertaining to daily functioning
    Perform within 1.5 standard deviation of age and education matched norms on screening
    tests of attention and executive function, language, visuospatial perception and
    episodic memory
    Stable medications for at least 30 days
    Fluent in English
    Modified Hachinski Score of <4
    Geriatric Depression Scale Score <10

You may not be eligible for this study if the following are true:

  • Diagnosis of MCI or dementia
    Individuals with contraindications to MRI (i.e., implanted metal including
    pacemakers, cerebral spinal fluid shunts, aneurysm clips, artificial heart valves,
    ear implants or metal/foreign objects in the eyes and those with a history of
    claustrophobia)
    Unstable medications or on medications with CNS effects including cholinesterase
    inhibitors, memantine, and antidepressants
    Major psychiatric disorders such as schizophrenia, schizoaffective disorder, major
    affective disorder, or treatment with ECT (mild depression that is well treated with
    table dose of SSRI antidepressants will be allowed)
    Multiple sclerosis or other autoimmune disorders
    Huntington's disease
    Head injury, post-traumatic dementia or seizures
    Metabolic encephalopathy, CNS infection, hydrocephalus
    Cardiovascular disease, stroke, congestive heart failure
    Substance abuse within the past 2 years
    Active cancer
    Active hematological, renal, pulmonary, endocrine or hepatic disorders

Recruitment Status: Open


Brief Description Eligibility Contact Research Team


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