Collection of Samples and Clinical Data From Patients With Amyloid Diseases

  • STATUS
    Recruiting
  • End date
    Feb 22, 2037
  • participants needed
    10000
  • sponsor
    Boston Medical Center
Updated on 22 March 2022

Summary

RATIONALE: Collecting and storing samples of blood, urine, tissue and data from patients with amyloid diseases to test in the laboratory may help the study of this disease in the future.

PURPOSE: This research study is collecting samples from patients with amyloid diseases

Description

OBJECTIVES
  • To establish and maintain a database of clinical material (i.e., blood, urine, and tissue) and information on patients with amyloid diseases.

OUTLINE: Blood, urine, tissue, and bone marrow samples are collected during standard laboratory evaluations to maintain a repository of biospecimens in the Gerry Amyloid Research Laboratory, to permit the correlation of clinical results with measured biological events, and for future research studies. Bone marrow RNA samples are examined for immunoglobulin light-chain gene sequences and amino acids by polymerase chain reaction and positional cloning. Blood serum and urine samples are evaluated for amyloid protein stability by high-resolution calorimetry, isothermal-titration calorimetry, and far- and near-UV circular dichroism and fluorescence spectroscopy. Urine samples are also examined for post-translational modifications (e.g., glycosylation, sulfation, and cross-linking) to identify common features unique to amyloid proteins. Tissue samples are analyzed for biochemical and biophysical properties and for post-translational modifications in light chains.

Quality of life is assessed by the 36-Item Short Form Survey (SF-36).

Details
Condition Multiple Myeloma
Treatment laboratory biomarker analysis, quality-of-life assessment, polymerase chain reaction, biologic sample preservation procedure, protein analysis, clonality analysis, fluorescence spectroscopy, fluorescence spectroscopy
Clinical Study IdentifierNCT00898235
SponsorBoston Medical Center
Last Modified on22 March 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

DISEASE CHARACTERISTICS
Diagnosis or suspicion of amyloidosis
PATIENT CHARACTERISTICS
Referred to the Amyloid Treatment and Research Center at Boston University Medical Center
PRIOR CONCURRENT THERAPY
Not specified

Exclusion Criteria

None
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