Multidrug Resistance Proteins in Patients Enrolled in Clinical Trials Outside of the National Cancer Institute Center for Cancer Research
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- STATUS
- Recruiting
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- participants needed
- 9999
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- sponsor
- National Cancer Institute (NCI)
Summary
RATIONALE: Studying samples of tumor tissue or blood from patients with cancer in the laboratory may help doctors learn more about cancer and the development of multidrug resistance in patients. PURPOSE: This laboratory study is looking at multidrug resistance proteins in patients enrolled in clinical trials outside of the National Cancer Institute Center for Cancer Research.
Description
OBJECTIVES: - Determine expression of MDR-1 gene/P-glycoprotein and related drug resistance proteins in tumor tissue samples from patients enrolled in clinical trials outside of the National Cancer Institute Center for Cancer Research. OUTLINE: Tumor tissue or blood samples that have been previously collected from patients are analyzed for P-glycoprotein and other multidrug transporters (e.g., MRP-1 and ABCG2) by immunohistochemistry, microarray analysis, and reverse transcriptase-polymerase chain reaction. The identity of individual patients remains confidential. No results of sample analyses are provided to patients or family members. PROJECTED ACCRUAL: An unlimited number of patient samples will be accrued for this study.
Details
| Condition | Brain and Central Nervous System Tumors, Breast Cancer, Unspecified Adult Solid Tumor, Protocol Specific, Unspecified Childhood Solid Tumor, Protocol Specific |
|---|---|
| Treatment | flow cytometry, immunohistochemistry staining method, Gene Expression Analysis, protein expression analysis, reverse transcriptase-polymerase chain reaction |
| Clinical Study Identifier | NCT00898001 |
| Sponsor | National Cancer Institute (NCI) |
| Last Modified on | 7 November 2020 |
Eligibility
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