Dose-escalation Study of Oral CX-4945
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- STATUS
- Recruiting
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- participants needed
- 55
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- sponsor
- Cylene Pharmaceuticals
Summary
This Phase 1 study of oral CX-4945 is designed to test the safety, tolerability and highest safe dose level of this CK2 inhibitor in patients with advanced solid tumor cancers, Castleman's Disease or Multiple Myeloma.
Description
Elevated CK2 activity has been associated with malignant transformation and aggressive tumor growth and overexpression of CK2 has been documented in multiple types of cancer. CK2 has emerged as a potential anticancer target and inhibition of CK2 represents a potential therapeutic strategy to target a specific molecular defect perpetuating many cancers. CX-4945 has demonstrated potent inhibition of CK2 enzymatic activity. This study will evaluate the safety, pharmacokinetics (PK), and pharmacodynamic (PD) effects of CX-4945 administered to patients with malignancies or lymphoproliferative disorders known to overexpress CK2 including advanced solid tumors, Multiple Myeloma and Castleman's Disease.
Details
| Condition | Castleman's Disease, Multiple Myeloma, Breast Cancer, Inflammatory Breast Cancer |
|---|---|
| Treatment | CX-4945 oral formulation |
| Clinical Study Identifier | NCT00891280 |
| Sponsor | Cylene Pharmaceuticals |
| Last Modified on | 7 November 2020 |
Eligibility
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