Magnetic Resonance (MR) Imaging to Determine High Risk Areas in Patients With Malignant Gliomas and to Design Potential Radiation Plans and to Examine Metabolite Changes in Gliomas and Other Solid Tumors

  • End date
    Sep 20, 2023
  • participants needed
  • sponsor
    Memorial Sloan Kettering Cancer Center
Updated on 7 October 2022
malignant glioma
brain tumor


The researchers think that the use of advanced MR imaging may help people with this disease, because it may better predict areas within a malignant glioma (brain tumor) that are at a high risk of recurring. WeThe reserchers are doing this study to see whether this advanced imaging is a safe treatment that causes few or mild side effects in people with brain tumors.

Condition Brain Cancer, Glioma
Treatment MRI and advanced MRI sequences
Clinical Study IdentifierNCT00870129
SponsorMemorial Sloan Kettering Cancer Center
Last Modified on7 October 2022


Yes No Not Sure

Inclusion Criteria

Suspected or Histopathologically proven diagnosis of high grade or low glioma or tumor is suspected to harbor an isocitrate dehydrogenase (IDH) mutation
May undergo radiation therapy
Patient and/or guardian is able to provide written informed consent prior to study registration
Age ≥ 18 years old

Exclusion Criteria

Extreme claustrophobia that precludes MRI scan
Known allergic reaction to Gd-DTPA
Any contraindication to gadolinium intravenous contrast as per standard Department of Radiology contrast guidelines
Any absolute contraindication to MRI (e.g., pacemaker, aneurysm clip, tissue expander)
Pregnant or nursing female
Unable to cooperate for MRI and/or radiation therapy planning
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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