Last updated on March 2009

Donepezil and Memantine in Moderate to Severe Alzheimer's Disease

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Moderate to Severe Alzheimer's Disease
  • Age: - 100 Years
  • Gender: Male or Female
  • Other:
    Participants will be patients who meet NINCDS-ADRDA criteria for probable or possible
    Alzheimer's disease (McKhann et al, 1984). In addition they will meet all of the following
    SMMSE = 5 to 13 (13 chosen as NICE threshold of 10 plus 1 SD on SMMSE score)
    Continuously prescribed donepezil for at least 3 months
    Maintained on 10mg donepezil in previous 6 weeks.
    No changes in prescription of any psychotropic (antipsychotic, antidepressant,
    benzodiazepine) medication in previous 6 weeks.
    Prescribing clinician considers (based on NICE guidance, discussions with patient and
    carer and clinical judgement) that change of drug treatment (i.e. stop donepezil or
    introduce memantine) may be appropriate.
    Patient is community resident and has family or professional carer or is visited on
    at least a daily basis by carer.
    Patient agrees to participate if considered capable (see section 7.5)
    Main carer (informal or professional) consents to their own involvement and the
    patient's involvement -

You may not be eligible for this study if the following are true:

  • To maximise the generalisability of the study data, exclusions will be kept to a minimum.
    These will include:
    Patient has severe, unstable or poorly controlled medical conditions apparent from
    physical examination or clinical history.
    Patient is already prescribed memantine.
    Patient is unable to take trial medications because of contra-indications or previous
    adverse or allergic reactions.
    Patient is involved in another clinical trial.
    Clinician considers patient would not be compliant with trial medication. -

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

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