Last updated on April 2014

Detection of Subclinical Atherosclerosis in Asymptomatic Individuals

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Coronary Artery Disease
  • Age: Between 35 - 90 Years
  • Gender: Male or Female
  • Other:
    Males between ages 35-90 or females between ages 40-90
    No known coronary artery disease
    no prior coronary disease by cardiac catheterization (no more than 40% in any
    major epicardial vessel)
    no prior myocardial infarction
    no prior ST-elevation myocardial infarction (1 mm ST-elevation in 2 contiguous
    no prior non-ST-elevation myocardial infarction (CK-MB > 2x ULN or elevated
    troponin that is indicative of myocardial necrosis based on local institutional
    no prior coronary revascularization procedure
    no chest pain, shortness of breath, angina or angina-equivalent that is assumed
    to be related to myocardial ischemia
    Presence of a high-risk feature (at least one of the following four will quality)
    High FRS ≥20% (
    Diabetes Mellitus
    Premature CAD in a first-degree relative
    High Risk Lipid Profile (must meet one of the following laboratory criteria)
    LDL > 250 mg/dL
    HDL < 20 mg/dL
    Triglycerides > 1000 mg/dL
    LP(a) > 80 mg/dL
    Provide written informed consent and Authorization for Use/Disclosure of PHI

You may not be eligible for this study if the following are true:

  • Known genetic form of hypercholesterolemia based on clinical criteria (e.g. familial
    hypercholesterolemia, etc.)
    Creatinine 1.5 mg/dL or greater
    Irregular rhythm precluding cardiac CT examination
    Uncontrolled hypertension (SBP>210 mmHg or DBP>140 mmHg on treatment)
    Known moderate or severe allergy to iodine-based contrast agents (mild prior
    reactions that could be treated as an outpatient or that could be prevented by
    pre-medication in the past do not constitute exclusion)
    Known Pregnancy
    Unwilling or unable to consent
    Presence of any co-morbidity that makes life expectancy less than 24 months
    Unwilling or unable to complete follow-up
    Unwilling or unable to provide written informed consent and Authorization for
    Use/Disclosure of PHI

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

Volunteer Sign-up

Sign up for our FREE service to receive email notifications when clinical trials are posted in the medical category of interest to you.