Safety Study of Calcineurin Inhibitor Free GvHD Prophylaxis in Allogeneic Stem Cell Transplantation

  • STATUS
    Recruiting
  • participants needed
    38
  • sponsor
    University Hospital Freiburg
Updated on 7 November 2020
cancer
chronic myeloid leukemia
graft versus host disease
hematologic malignancy
blast crisis
lymphoma
hodgkin's disease
everolimus
cell transplantation
leukemia
blood transfusion
chronic myelomonocytic leukaemia
lymphoblastic leukemia

Summary

In stem cell transplantation as treatment for malignant diseases, calcineurin inhibitors like cyclosporine A are commonly used to prevent tissue destruction (GvHD) by activated donor immune cells. The hypothesis for this study is, that replacing calcineurin inhibitors by everolimus and mycophenolate as GvHD prophylaxis not only reduces toxicity of the treatment but also improves tolerance induction of the donor T cells toward the host, eventually increasing the safety of stem cell transplantation.

Details
Condition Blood disorder
Treatment Everolimus and mycophenolate sodium
Clinical Study IdentifierNCT00856505
SponsorUniversity Hospital Freiburg
Last Modified on7 November 2020

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