Sorafenib and FOLFIRI Regimen in 2nd Colorectal Cancer (CRC) After Failure of Oxaliplatin Treatment

  • STATUS
    Recruiting
  • participants needed
    43
  • sponsor
    Fudan University
Updated on 7 November 2020
platelet count
metastasis
oxaliplatin
neutrophil count
adenocarcinoma
adjuvant chemotherapy
folfiri regimen
adenocarcinoma of colon

Summary

The purpose of this study is to evaluate the Progression-Free Survival (PFS) time of Sorafenib in combination with FOLFIRI regimen used as in the second front treatment in patients with advanced CRC after failure of oxaliplatin treatment.

Description

This is a phase Ⅱ open label, non randomized study, in which sorafenib is used in combination with irinotecan, leucovorin and fluorouracil in patients with advanced colorectal cancer after failure of oxaliplatin treatment.The aim of this study is to determine the Progression-Free Survival (PFS) of Sorafenib used in combination with FOLFIRI regimen as a second front treatment in patients with advanced CRC after failure of oxaliplatin treatment, defined as the time from treatment to disease progression or death due to any cause. The other secondary endpoints are disease control rate, defined as complete response, partial response, and stable disease.Response rate,overall survival, and safety are also evaluated.

Details
Condition Colorectal Cancer
Treatment Sorafenib, FOLFIRI
Clinical Study IdentifierNCT00839111
SponsorFudan University
Last Modified on7 November 2020

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