Last updated on September 2013

Comparing Treatments for Self-Injury and Suicidal Behavior in People With Borderline Personality Disorder

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Suicide | Borderline Personality Disorder
  • Age: Between 18 - 65 Years
  • Gender: Male or Female
  • Other:
    Meets DSM-IV criteria for borderline personality disorder (BPD)
    Attempted suicide in the past 2 months
    At least one additional suicide attempt, suicide-related behavior, or self-injury
    episode in the past year
    Current suicidal ideation
    Able to be managed as an outpatient
    Not currently receiving optimum psychiatric treatment and agrees to notify study
    taff if any psychiatric care outside this study is sought. If care other than that
    permitted by the protocol is utilized, participants can no longer be enrolled in the
    Has a stable living arrangement at study entry
    Speaks English
    Willing and judged to be clinically able to undergo wash-out of psychotropic
    medications, except for occasional benzodiazepine use, for 2 to 6 weeks before
    Females must be willing to use an effective method of birth control.

You may not be eligible for this study if the following are true:

  • Meets the DSM-IV criteria for mental retardation or the following disorders: bipolar
    I, schizophrenia, delusional disorder, schizophreniform disorder, schizoaffective
    disorder, or psychotic disorder not otherwise specified (NOS)
    Needs priority treatment for acute medical illness or other debilitating problem,
    uch as severe substance dependence or anorexia
    Clinically too unstable to be maintained as an outpatient
    Has clearly failed adequate trials of fluoxetine and citalopram for a major
    depression in the past 2 years
    History of severe allergies, adverse drug reactions, or known allergy to fluoxetine
    or citalopram
    Clinically inadvisable for the participant to end current treatment
    Heart pacemaker body implant; other metal implants, such as shrapnel or surgical
    prostheses; or paramagnetic objects contained within the body, as assessed via a
    metal screening questionnaire, which may present a risk to the participant or
    interfere with the fMRI scan
    Diagnosed with Raynaud's disorder
    History of hypertension, cardiovascular disease, or abnormal electrocardiograms
    Claustrophobia or significant discomfort in enclosed space

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

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