Sorafenib and LBH589 in Hepatocellular Carcinoma (HCC)

  • STATUS
    Not Recruiting
  • participants needed
    18
  • sponsor
    University of Erlangen-Nürnberg
Updated on 26 January 2021
Investigator
Matthias Ocker, MD
Primary Contact
Department of Medicine 1, University Hospital Erlangen (8.7 mi away) Contact
cancer
cirrhosis
neutrophil count
erlotinib
radiofrequency ablation
sorafenib
ethanol injection
chemoembolization
percutaneous ethanol injection
antineoplastic
local therapy
arterial embolization

Summary

Histone deacetylase inhibitors (HDACi) like LBH589 have recently been established as novel potent anti-cancer agents for solid and hematologic malignancies. Several pre-clinical reports have shown a good anti-tumoral activity of different HDACi on human or murine HCC models. These compounds, e.g. Trichostatin A, SAHA, MS-275 and others, have been shown to induce apoptosis in HCC cells and to inhibit growth of HCC by inhibiting proliferation and tumor-related angiogenesis in vivo. Furthermore, HDACi sensitize HCC in a synergistic manner to other forms of cytotoxic stimulation, e.g. by conventional chemotherapeutic drugs or TRAIL-mediated apoptosis. It has also been shown that the combination of HDACi with various kinase inhibitors like sorafenib, erlotinib or others, promotes the anti-tumor efficacy of single agents. Based on the investigators' own previous experiences with different HDACi and LBH589 in preclinical HCC models, a strong anti-proliferative and pro-apoptotic as well as an anti-angiogenic effect will be expected by combining LBH589 with an existing sorafenib treatment. It is assumed that this combination will prolong overall survival and time-to-progression with lowered adverse effects in HCC patients.

Details
Condition HEPATOCELLULAR CARCINOMA
Treatment Sorafenib + LBH589
Clinical Study IdentifierNCT00823290
SponsorUniversity of Erlangen-Nürnberg
Last Modified on26 January 2021

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