Sonazoid Enhanced Liver Cancer Trial for Early Detection

  • participants needed
  • sponsor
    Japan Liver Oncology Group
Updated on 7 November 2020
liver cancer


The aim of this study is to prove usefulness of contrast-enhanced ultrasound (CE-US) using Sonazoid (TM) in the early detection of HCC as compared with conventional B-mode ultrasound (B-mode US) for hepatitis virus related cirrhosis, who are defined as super high-risk patients for hepatocarcinogenesis,Furthermore, to analyze whether early detection of HCC by CE-US has a survival benefit than that by B-mode US.

Condition Cirrhosis, Hepatitis B, Hepatitis C, Hepatitis C virus, HEPATOCELLULAR CARCINOMA
Treatment CE-US (Sonazoid™), B-mode US
Clinical Study IdentifierNCT00822991
SponsorJapan Liver Oncology Group
Last Modified on7 November 2020


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Inclusion Criteria

Is your age greater than or equal to 20 yrs?
Gender: Male or Female
Do you have any of these conditions: Cirrhosis or HEPATOCELLULAR CARCINOMA or Hepatitis B or Hepatitis C virus or Hepatitis C?
Age over 20
HBV or HCV related liver cirrhosis
No history of HCC
Diagnosed as liver cirrhosis histologically or clinically Histologically confirmed by liver biopsy Confirmed by formula of diagnosing cirrhosis Radiological finding Finding of portal hypertension Platelet<130,000
Inpatient or outpatient
Patients who signed a written informed consent form

Exclusion Criteria

History of hypersensitivity to egg yolk
Pregnant or lactating women and women who may be pregnant
Severe liver dysfunction(AST, ALT,or BIL level >10ULN
Associated with HCC
Patients receiving interferon
Age under 20
Judged by investigator not to be appropriate for inclusion in this study
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