FOLFOX4 Combined With Endostar in Patients With Advanced Colorectal Cancer

  • STATUS
    Recruiting
  • participants needed
    120
  • sponsor
    Simcere Pharmaceutical Co., Ltd
Updated on 7 November 2020
measurable disease
avastin
lung cancer

Summary

FOLFOX4 plus Avastin has been suggested as firstline regimen for advanced colorectal cancer by NCCN, a new angiogenesis inhibitor, known as Endostar(Recombinant Human Endostatin), prolonged the overall survival, time to progression and improved response rate in metastatic lung cancer in a large phase III clinical trial in china, so we design this trial to evaluate the safty and efficacy of FolFox4 plus Endostar in patients with advanced colorectal cancer

Description

Endostar is free supported by Shangdong Simcere Medgene biotech co.,Ltd. Endostar combination with Chemotherapy has been the first line treatment regimen to advanced NSCLC. Clinical data proved that Endostar was a wild spectrum and safe antiangiogenesis factor which could suppress almost 65 kinds of tumor mass in animal models and affect about 12 percent human genome. China NCCN colon or rectal cancer clinical practice guideline recommends Chemotherapy plus angiogenesis inhibitor as the first line treatment scheme. So we design FOLFOX4 plus Endostar to treat advanced colorectal cancer to research the RR and safety. We believe this treatment regimen may be a new approach to the advanced colorectal cancer patients.

Details
Condition Colorectal Cancer
Treatment Folfox4 plus recombinant human endostatin (Endostar)
Clinical Study IdentifierNCT00813137
SponsorSimcere Pharmaceutical Co., Ltd
Last Modified on7 November 2020

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