Sleep Apnea in Cerebrovascular Disease

  • participants needed
  • sponsor
    Yale University
Updated on 7 November 2020
sleep apnea


This study seeks to evaluate a diagnostic and therapeutic intervention strategy among veterans with cerebrovascular disease, hypertension and obesity that consists of using unattended sleep studies to diagnose sleep apnea and CPAP to treat sleep apnea. It is hypothesized that the intervention strategy will (1) reduce hypertension at the end of the one-year study period, (2)reduce daytime sleepiness, (3)result in improved cognitive function, (4) result in improved quality of life and(4) will increase the rate and treatment of diagnosed sleep apnea.


The study will evaluate a diagnostic/therapeutic intervention among veterans with cerebrovascular disease, hypertension, and obesity using unattended polysomnography to diagnose sleep apnea and CPAP with an adherence/educational protocol to treat sleep apnea. Electronic databases will be used to identify patients at two VA medical centers with cerebrovascular disease (stroke or Transient Ischemic Attack (TIA)) who have hypertension and obesity. The patients will be randomly assigned to the intervention arm (N=167) or the control (usual care) arm (N=167). Patients in the intervention arm who have sleep apnea will receive auto-titrating CPAP therapy for one year. Control patients will receive usual care and their primary care providers will be notified that they are at risk for having sleep apnea; control patients will receive unattended polysomnography at the end of the one-year study period.Twenty-four hour blood pressure will be measured in both groups at baseline and after one year.

Condition Cerebrovascular Stroke, Transient Ischemic Attack, Sleep Apnea, Blood Pressure, High
Treatment CPAP Treatment
Clinical Study IdentifierNCT00807417
SponsorYale University
Last Modified on7 November 2020


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