High-Dose Sequential Chemoimmunotherapy for B-Cell Lymphomas With Central Nervous System Involvement

  • STATUS
    Recruiting
  • participants needed
    38
  • sponsor
    IRCCS San Raffaele
Updated on 22 January 2022
cancer
remission
cyclophosphamide
methotrexate
cytarabine
rituximab
etoposide
cancer chemotherapy
chemoimmunotherapy

Summary

This prospective trial will assess the activity and feasibility of a new high-dose methotrexate-based high-dose sequential chemotherapy combination in patients with B-cell lymphomas and CNS involvement at diagnosis or relapse. Selected drugs, with a well-documented anti-lymphoma activity, will be administered at high doses to increase blood-brain barrier penetration and CNS bioavailability as well as to reduce potential cross-resistance.

Description

Patients with aggressive B-cell lymphoma and involvement of the central nervous system at diagnosis or relapse will be treated with a combination of high-dose methotrexate and high-dose cytarabine, rituximab, and intrathecal depocyte followed by rituximab-high-dose sequential chemotherapy supported by autologous tsem cell transplantation.

Details
Condition B-Cell Lymphomas
Treatment High-dose sequential chemotherapy and autologous transplant
Clinical Study IdentifierNCT00801216
SponsorIRCCS San Raffaele
Last Modified on22 January 2022

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