Antiretroviral Therapy for Acute and Chronic HIV Infection (AAHIV)

  • STATUS
    Recruiting
  • End date
    Jun 26, 2033
  • participants needed
    644
  • sponsor
    South East Asia Research Collaboration with Hawaii
Updated on 23 January 2022

Summary

This is a protocol designed to randomize subjects with acute HIV infection to receive standard HAART or mega-HAART for subject who are enrolled in SEARCH 010 study (protocol title: Establish and characterize an acute HIV infection cohort in a Thai high risk population.

To describe the impact of standard HAART versus mega-HAART initiated during the acute HIV infection period on immunological and virological outcomes.

Description

HIV-1 plasma viral RNA measurements and CD4 counts during follow-up and after therapy

Number of HIV and non-HIV related clinical events Adverse events related to HAART Adherence to HAART Resistance to antiretroviral medications

Details
Condition Acute HIV Infection, Chronic HIV Infection
Treatment HAART, Mega-HAART
Clinical Study IdentifierNCT00796263
SponsorSouth East Asia Research Collaboration with Hawaii
Last Modified on23 January 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Age 18 years old
Enrolled in SEARCH 010 protocol and have protocol-defined acute HIV-1 infection (Tested 4th generation HIV EIA negative and NAT positive or tested 4th generation HIV EIA positive, negative by less sensitive EIA and NAT positive)
Choose to start HAART according to protocol
Understand the study and sign informed consent form. Persons who cannot read will have the consent form read to them by a study staff and they can give informed consent by using thumb print
Availability for follow-up for the planned study duration

Exclusion Criteria

Persons who have a history of a medical or psychiatric disorder by investigator's interview and physical examination according to standard practices, that in the judgment of the investigator(s), would interfere with or serve as a contraindication to adherence to the study protocol or ability to give informed consent
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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