Deep Transcranial Magnetic Stimulation in Patients With Alzheimer's Disease

  • participants needed
  • sponsor
    Tel-Aviv Sourasky Medical Center
Updated on 7 November 2020
mini-mental state examination


The primary objective of this trial is to assess the ability of Transcranial Magnetic Stimulation with H2 coil to prefrontal and parieto-temporal cortex to improve cognitive performance in patients with Alzheimer's disease which received drug treatment. This study is a single-center, double-blind 4 months duration trial.


Primary outcome measure: ADAS-COG (time frame baseline, 2 months, 4 months) Secondary outcome measure: CGI-C, Neuropsychological computerized test (Mindstream), FAB,ADL, Beck Depression Inventory-time frame baseline,1 month (visit 12) 2 months (visit 16), 4 months (visit 17). Estimated enrollment: 45 patients Estimated Study start Date: November 2008 Estimated Study Completion date: November 2012 Number of arms: 3 Interventions details: H2 coil device for Transcranial Magnetic Stimulation with MAGSTIM to prefrontal and parieto-temporal regions bilaterally with frequency 10Hz in one arm, 1Hz in the second arm, and sham-stimulation with frequency 10Hz/1Hz in third arm. Ages: 50-80 Genders: both

Condition Alzheimer's Disease
Treatment 1Hz TMS with H2 coil, 10Hz TMS with H2 coil to prefrontal and parieto-temporal cortex, SHAM TMS with H2 coil
Clinical Study IdentifierNCT00753662
SponsorTel-Aviv Sourasky Medical Center
Last Modified on7 November 2020


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